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Clinical Trials in Norway / NCT06364163
Active, not recruiting Not applicable

Effect of Herring Oil Concentrate on LDL Cholesterol Concentration in Adults

NCT06364163 · tracked via the Priya Life Science Norway tracker
Sponsor
University of Bergen
Phase
Not applicable
Started
2024-08-12
Last updated
2025-10-02

Condition(s) studied

High Cholesterol

Investigational drug(s) / intervention(s)

Herring oil concentrateControl

Herring oil concentrate: Capsules containing herring oil concentrate, taken daily for 8 weeks.

Control: Capsules containing control oil, taken daily for 8 weeks.

Study summary

High cholesterol concentration is a major risk factor for cardiovascular disease (CVD), and consumption of fish has been associated with a lower CVD risk in several studies. The beneficial health effects of consuming fish have traditionally been ascribed to the long-chain PUFA (LC-PUFA) EPA (C20:5n-3) and DHA (C22:6n-3), although consumption of fish oils or concentrates with high EPA and DHA contents does not affect the cholesterol concentration in humans and lowers the cholesterol concentration in rats and mice only when given in very high doses. Fish oils contain a plethora of fatty acids besides EPA and DHA, and in recent years, increased focus has been on the long-chain MUFA (LC-MUFA) cetoleic acid (C22:1n-11). Cetoleic acid is found in high amounts in oils from certain fish species such as herring, which has relatively low contents of both EPA and DHA. The investigators have recently summarised and meta-analysed the available literature that investigates the effects of diets containing fish oils or fish oil concentrates that have a high content of cetoleic acid but low or no content of EPA and DHA on cholesterol concentration in rodents, showing that cetoleic acid-rich fish oils and concentrates prevent high cholesterol concentration.

Eligibility

Sex
ALL
Min age
20 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria: * BMI over 25 kg/m2 * Stable body weight last 3 months Exclusion Criteria: * Allergies towards fish, milk, egg, gluten * Tobacco use (cigarettes or snus) * Diseases affecting the heart, intestinal function, kidney function or insulin secretion * Use of medications targeting cholesterol -or glucose metabolism * Use of dietary supplements * Pregnant or breastfeeding * Following a strict diet * Had bariatric surgery or using medications for weight loss * Recent or planned surgical procedures * High intake of fish/seafood

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
University of Bergen Bergen Norway

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06364163 on ClinicalTrials.gov ↗ ← All trials in Norway