Pain Predict Genetics

Condition(s) studied

Study summary

Pain is the most frequent cause of suffering and disability in society. Despite considerable involvement of genetic factors in pain sensation and sensitivity, the individual genes involved remain largely unidentified.

In this project the investigators will follow patients undergoing elective major surgery for the development of acute and chronic pain. The investigators will search for clinical as well as genetic factors that can predict the development of pain. These can serve as biomarkers to predict acute and chronic pain development and progression in individual patients and help early individual treatment adaptation.

Eligibility

Primary outcome measure(s)

• Genetic risk factors for the development of acute pain using a visual analogue scale. — 7 days
  All patients will be followed for 1 year after elective surgery, during this period the investigators will collect acute pain measures using a visual analogue scale (ranging from 0 (no pain) -10 (pain)) before the operation and 1, 2, 3 and 7 days after the operation.
• Genetic risk factors for the development of chronic pain (defined as pain (yes or no) for more than 3 months in one specific body area). — 6 months
  All patients will be followed for 1 year after elective surgery, during this period the investigators will collect chronic pain measures using a questionnaire before the operation and 1 week, 3 months and 6 months. Chronic pain is defined as pain at a specific body side (yes/no) for more than 3 months.

Trial sites (1)

More Radboud University Medical Center trials in the Netherlands

Other trials for the same condition