OSNA: The search for lymph node metastases in surgically removed sentinel lymph nodes will occur using the OSNA method
Ultrastaging: The search for lymph node metastases in surgically removed sentinel lymph nodes will occur using the ultrastaging method
Study summary
Patients enrolled in the study will be randomized before surgery: in one study arm, the search for lymph node metastases in surgically removed sentinel lymph nodes will occur using the ultrastaging method (standard), while in the other arm it will be conducted using the OSNA method.
Eligibility
Sex
FEMALE
Min age
—
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Histologically confirmed endometrial cancer
* Apparent (pre-operative) FIGO stage I-II
* Radical surgery
* Attempt of SLN mapping
Exclusion Criteria:
* Uterine sarcoma (including endometrial stromal sarcoma)
* Fertility sparing surgery
* Dedifferentiated histology
* Undifferentiated histology
* Neoadjuvant therapy
* Previous surgery to pelvic lymph nodes
* Lymph nodes with short axis \>15 mm at pre-operative imaging
Primary outcome measure(s)
Number of SLN metastasis detected by OSNA versus ultrastaging method — From enrollment to the acquisition of the histological examination (8 weeks) We will evaluate the number of lymph node metastases identified with both methods, in order to calculate the incidence of lymph node metastases for each group
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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