A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 Diabetes
Condition(s) studied
Investigational drug(s) / intervention(s)
CagriSema (Cagrilintide B and Semaglutide I): Cagrilintide B and Semaglutide I will be administered subcutaneously using DV3384 pen-injector.
Placebo matched to CagriSema (Cagrilintide B and Semaglutide I): Placebo matched to Cagrilintide B and Placebo matched to Semaglutide I will be administered subcutaneously using DV3384 pen-injector.
Study summary
The purpose of this clinical study is to look into how well a study medicine called CagriSema helps children and adolescents living with diabetes lower their blood sugar and body weight. The study has 2 parts: in the first part participant will get either CagriSema or placebo, and in the second part participant will get CagriSema. In the first part, which treatment participant gets is decided by chance and second part is open label and all participants will get CagriSema during this part. The study will last for about 1 year and 3 months.
Eligibility
Primary outcome measure(s)
- Change in glycated haemoglobin (HbA1c) — From baseline (week 0) to end of double-blinded treatment (week 26)
Measured as percentage (%) of HbA1c.
Trial sites (58)
| Facility | City | Region | Status |
|---|---|---|---|
| Yale School of Medicine | New Haven | Connecticut | Not Yet Recruiting |
| Encore Medical Research Boynton Beach | Boynton Beach | Florida | Recruiting |
| Nemours Chld Clnc Jacksonville | Jacksonville | Florida | Recruiting |
| Innovus Clinical | Kissimmee | Florida | Recruiting |
| D&H National Research Centers | Tamarac | Florida | Recruiting |
| Clinical Research Trials of Florida | Tampa | Florida | Recruiting |
| Columbus Research Foundation | Columbus | Georgia | Recruiting |
| Eastside Bariatric and Gen Surg | Snellville | Georgia | Recruiting |
| SIU Medicine | Springfield | Illinois | Not Yet Recruiting |
| Riley Hospital For Children | Indianapolis | Indiana | Not Yet Recruiting |
| University of Iowa | Iowa City | Iowa | Recruiting |
| Great Lakes Research Inst. | Southfield | Michigan | Recruiting |
| UBMD Pediatrics | Buffalo | New York | Not Yet Recruiting |
| NYU Langone Orthopedic Center | New York | New York | Not Yet Recruiting |
| Children's Hosptl Philadelphia | Philadelphia | Pennsylvania | Not Yet Recruiting |
| Monument Health Clinical Rsrch | Rapid City | South Dakota | Not Yet Recruiting |
| LifeDoc Health | Memphis | Tennessee | Recruiting |
| Amir Ali Hassan, MD, PA | Houston | Texas | Recruiting |
| Consano Clinical Research, LLC | Shavano Park | Texas | Recruiting |
| UVA Health Systems | Charlottesville | Virginia | Recruiting |
| Seattle Children's Research Institute | Seattle | Washington | Recruiting |
| Centro de Investigaciones Metabólicas | Capital Federal | Buenos Aires | Recruiting |
| Centro de Investigación C.I.C.E 9 de Julio - Sanatorio 9 de Julio | San Miguel de Tucumán | Tucumán Province | Recruiting |
| IMOBA | City of Buenos Aires | Argentina | Recruiting |
| CIPADI | Godoy Cruz | Argentina | Not Yet Recruiting |
| Clínica Mayo de Urgencias Médicas Cruz Blanca | San Miguel de Tucumán | Argentina | Recruiting |
| Hospital Universitário Walter Cantídio | Bairro Rodolfo Teófilo, Fortaleza | Ceará | Recruiting |
| Centro de Diabetes Curitiba | Curitiba | Paraná | Recruiting |
| Instituto da Criança com Diabetes - ICD | Porto Alegre | Rio Grande do Sul | Not Yet Recruiting |
| Unidade de Pesquisa Clínica do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo | Ribeirão Preto | São Paulo | Not Yet Recruiting |
| IBTED Tecnologia e Educação em Diabetes - EPP | São Paulo | São Paulo | Recruiting |
| Instituto da Criança e do Adolescente do HCFMUSP | São Paulo | São Paulo | Recruiting |
| Salud SURA Industriales | Bogotá | Antioquia | Not Yet Recruiting |
| Fundacion Valle del Lili | Cali | Valle del Cauca Department | Not Yet Recruiting |
| Endolife Specialty Hospitals | Guntur | Andhra Pradesh | Not Yet Recruiting |
| BAPS Pramukh Swami Hospital | Surat | Gujarat | Not Yet Recruiting |
| Indira Gandhi Institute of child health | Bangalore | Karnataka | Not Yet Recruiting |
| Sir Ganga Ram Hospital | New Delhi | National Capital Territory of Delhi | Not Yet Recruiting |
| Maulana Azad Medical College | Delhi | New Delhi | Not Yet Recruiting |
| Regency Hospital | Kanpur | Uttar Pradesh | Not Yet Recruiting |
+ 18 more sites — see the full list on the official registry below.
More Novo Nordisk A/S trials in India
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07282613 on ClinicalTrials.gov ↗ ← All trials in India