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Clinical Trials in India / NCT06679738
Starting soon Observational

Genetic Variants Associated With the Risk of Gall Stones and Cirrhosis.

NCT06679738 · tracked via the Priya Life Science India tracker
Sponsor
Institute of Liver and Biliary Sciences, India
Phase
Observational
Started
2024-11-10
Last updated
2024-11-07

Condition(s) studied

Liver CirrhosisGall Stone

Study summary

Gall stone disease is more common in patients with cirrhosis. This association has been well established in different studies. Among the various factors which predispose a patient with gall stone disease to have associated liver cirrhosis, genetics also plays an important role.

This study aims to do a genetic panel-based analysis of genes which are involved in cholestasis to find any association between liver cirrhosis and gall stone disease.

Patients with history of gall stone or history of cholecystectomy done for gall stone disease will be evaluated for the presence of liver cirrhosis by fibroscan and ultrasonography. Those patients with cirrhosis and without cirrhosis will undergo a panel based genetic test for the common cholestasis genes and multivariate analysis will be done for variants associated with lithogenesis and cirrhosis.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: 1. Patients \> 18 years of age. 2. Who has a GSD diagnosed by USG or have history of cholecystectomy for gall stone disease. 3. Who is a diagnosed case of cirrhosis by Fibroscan or USG (Cirrhosis including alcohol related cirrhosis, Hepatitis B, Hepatitis C, Wilsons disease, Hemochromatosis are excluded. Exclusion Criteria: 1. Patients who have haemolytic anaemia 2. Patients who do not consent for genetic study 3. Patients who has a diagnosed cause for liver disease, including alcohol related cirrhosis, Hepatitis B, Hepatitis C, Wilsons disease, Hemochromatosis. 4. Inability to provide informed consent. 5. Cannot understand Hindi or English should be excluded since they will not be able to reply objectively to questionnaire.

Primary outcome measure(s)

  • Identification of genetic risk-variants associated with both GS and modulation of liver cirrhosis in patients with cirrhosis. — Day 0

Trial sites (1)

FacilityCityRegionStatus
Institute of Liver & Biliary Sciences New Delhi National Capital Territory of Delhi

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06679738 on ClinicalTrials.gov ↗ ← All trials in India