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Clinical Trials in France / NCT07882498
Recruiting Observational

Postoperative Pain Trajectories After Endometriosis Surgery

NCT07882498 · tracked via the Priya Life Science France tracker
Sponsor
Centre Hospitalier Universitaire, Amiens
Phase
Observational
Started
2026-07-07
Last updated
2026-10-20

Condition(s) studied

EndometriosisPostoperative PainPain TrajectoriesChronic Postsurgical PainQuantitative Sensory TestingCentral Sensitization

Investigational drug(s) / intervention(s)

Perioperative quantitative sensory testingquestionnaire

Perioperative quantitative sensory testing: Perioperative quantitative sensory testing (mechanical temporal summation and pressure pain thresholds)

questionnaire: Repeated administration of validated patient-reported outcome questionnaires

Study summary

The pain associated with endometriosis reflects a multifactorial pathophysiology combining peripheral nociception, central sensitisation and psychosocial factors. Although surgery is an integral part of treatment, a significant proportion of patients experience persistent pain several months after the procedure. To date, postoperative pain trajectories after endometriosis surgery remain poorly characterised, and there are no reliable predictors of chronic postoperative pain (CPP). This prospective, single-centre, longitudinal study aims to identify distinct postoperative pain trajectories and to assess whether perioperative quantitative sensory testing can predict the development of chronic postoperative pain at 3 and 6 months. Patients will undergo perioperative mechanical and pressure tests, including assessment of temporal summation and pressure pain thresholds, combined with validated measures of patient- reported outcomes. Follow-up assessments will be conducted on day 2, day 14, 1 month, 3 months, and 6 months after surgery to capture the dynamic evolution of pain, quality of life, fatigue, sexual function, and central sensitisation symptoms.

Eligibility

Sex
FEMALE
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Age ≥ 18 years * Imaging-confirmed endometriosis * Scheduled surgical treatment for endometriosis * Affiliation to the French Social Security system * Written informed consent obtained Exclusion Criteria: * Patients under legal protection (guardians or curators) * History of psychiatric disorders * Neurodegenerative diseases * Inability to self-assess pain using a numerical rating scale * Non-French-speaking patients * Pregnancy or breastfeeding * Refusal to participate

Primary outcome measure(s)

  • Brief Pain Inventory values for pain intensity and interference measurement — day 2
    Postoperative pain trajectories derived from repeated assessments of pain intensity and interference (Brief Pain Inventory) Brief Pain Inventory (BPI) is a questionnaire with 15 questions. For each question 0 is the smallest score and 10 is the highest score
  • EHP-5 values for quality of life measurement — day 2
    Postoperative pain trajectories derived from quality of life (EHP-5) EHP-5 (Endometriosis health profile 5) is a questionnaire with 10 questions
  • EHP-5 values for quality of life measurement — at 6 months
    Postoperative pain trajectories derived from quality of life (EHP-5) EHP-5 (Endometriosis health profile 5) is a questionnaire with 10 questions
  • FSFI values for sexual function measurement — day 2
    Postoperative pain trajectories derived sexual function (FSFI), Female Sexual Function Index (FSFI) is a questionnaire with 4 questions
  • FSFI values for sexual function measurement — at 6 months
    Postoperative pain trajectories derived sexual function (FSFI), Female Sexual Function Index (FSFI) is a questionnaire with 4 questions
  • Brief Pain Inventory values for pain intensity and interference measurements — at 6 months
    Postoperative pain trajectories derived from repeated assessments of pain intensity and interference (Brief Pain Inventory)
  • PROMIS Fatigue SF-6a values for fatigue measurement — day 2
    Postoperative pain trajectories derived from fatigue (PROMIS Fatigue SF-6a) PROMIS Fatigue SF-6a is a questionnaire with 6 questions
  • PROMIS Fatigue SF-6a values for fatigue measurement — at 6 months
    Postoperative pain trajectories derived from fatigue (PROMIS Fatigue SF-6a) PROMIS Fatigue SF-6a is a questionnaire with 6 questions
  • Convergences PP values for central sensitization symptoms measurement — day 2
    Postoperative pain trajectories derived from and central sensitization symptoms (Convergences PP) Score Convergence PP is a questionnaire with 4 questions
  • Convergences PP values for central sensitization symptoms measurement — at 6 months
    Postoperative pain trajectories derived from and central sensitization symptoms (Convergences PP) Score Convergence PP is a questionnaire with 4 questions

Trial sites (1)

FacilityCityRegionStatus
CHU Amiens-Picardie Amiens France Recruiting

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Other trials for the same condition

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Exposure to Persistent Organic Pollutants and Severity of Endometriosis in the ComPaRe-Endometriosis Cohort Starting soon
Treatment of Chronic Pelvic Pain Due to Endometriosis by Transcutaneous Auricular Vagus Nerve Stimulation Recruiting
Diagnostic and Prognostic Markers of Endometriosis in Menstrual Blood Recruiting
Impact on Quality of Life of Osteopathic Visceral Mobilizations After Endometriosis Surgery Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07882498 on ClinicalTrials.gov ↗ ← All trials in France