Salivary Replication of BK Virus in Post-kidney Transplant

Condition(s) studied

Investigational drug(s) / intervention(s)

Salivary self-collection: Salivary self-collection on the day of the kidney transplant then at 1, 3, 6, 9 and 12 months

Study summary

BK virus infection in kidney transplantation can compromise graft function. Current data suggest that BK virus nephropathy results not only from transmission of virus from the donor but also from reactivation of latent virus in the recipient. However, no study has investigated the possibility of respiratory transmission. This study would provide a better understanding of the pathophysiology of BK virus infection in kidney transplant recipients. The investigators would study viral replication of BK virus in saliva, urine and blood of patients who received a kidney transplant at the Amiens University Hospital. For this, the investigators will collect salivary self-collection on the day of the kidney transplant then at 1, 3, 6, 9 and 12 months as well as a urine and blood sample. The investigators will measure BK viral load in these three samples at different times.

Eligibility

Primary outcome measure(s)

• Number of BK positive saliva and blood samples — 12 months
  Compare the positivity of the BK virus viral load between the saliva sample and the urine and blood samples

Trial sites (1)

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