CMV-associated Immunomodulation in Renal Transplant Patients

NCT06976008 · tracked via the Priya Life Science France tracker

Sponsor

Assistance Publique - Hôpitaux de Paris

Phase

Not applicable

Started

2025-10-01

Last updated

2025-09-12

Condition(s) studied

Kidney Transplantation

Investigational drug(s) / intervention(s)

blood sampling

blood sampling: Blood samples will be taken at different timepoints following CMV viremia to evaluate the impact of CMV viremia over time.

Study summary

Cytomegalovirus (CMV) infection has been associated with an increased risk of bacterial, fungal and viral infections in solid organ transplant recipients. The purpose of this study to evaluate if the occurrence of CMV viremia modify the ability to develop optimal immune responses against other pathogens in kidney transplant recipients (heterologous immunity). The objective of this project is to identify the immune pathways affected by CMV in the context of immunosuppression associated with kidney transplantation.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: 1. st cohort : * Age \> 18 years * patients with end-stage renal failure programmed for kidney transplantation with a live donor 2. nd cohort : * Age \> 18 years * kidney transplant recipient with CMV viremia Exclusion Criteria: \- Patients under guardianship, curatorship, legal protection. For patients with end-stage renal failure scheduled to receive a kidney transplant from a living donor : * Patients with an active viral (other than CMV), bacterial or fungal infection at the time of inclusion * patients receiving a desensitization protocol (ABO or anti-HLA)

Primary outcome measure(s)

Impact of CMV infection on the heterologous innate immune response in kidney transplant patients — 12 months
Comparison of the amount of cytokine production after stimulation of innate immune cells with whole microorganisms (E. Coli, Candida, Aspergillus, influenza virus) in solid organ transplant recipients with and without CMV over time.

Trial sites (4)

Facility	City	Region
Hôpital Bicêtre	Le Kremlin-Bicêtre	France
Hôpital européen Georges Pompidou	Paris	France
Hôpital Necker-Enfants Malades	Paris	France
Insitut Pasteur	Paris	France

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06976008 on ClinicalTrials.gov ↗ ← All trials in France