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Clinical Trials in France / NCT07864116
Recruiting Observational

Basal LH Threshold for the Diagnosis of Central Precocious Puberty

NCT07864116 · tracked via the Priya Life Science France tracker
Sponsor
University Hospital, Strasbourg, France
Phase
Observational
Started
2026-03-02
Last updated
2026-10-07

Condition(s) studied

Precocious Puberty, Central

Study summary

This retrospective monocentric observational study aims to evaluate whether basal luteinizing hormone (LH) levels can reliably diagnose central precocious puberty and reduce the need for LHRH stimulation testing. Currently, all patients with suspected precocious puberty undergo LHRH testing regardless of basal LH levels.

The study will analyze pediatric patients evaluated between 2019 and 2024 to determine an optimal basal LH threshold with high specificity. Secondary analyses will assess diagnostic performance and explore clinical and biological factors influencing LH levels. The results may help reduce unnecessary testing and improve diagnostic strategies.

Eligibility

Sex
ALL
Min age
4 Years
Max age
11 Years
Healthy volunteers
No
Inclusion Criteria: * Children aged 4 to 11 years * Underwent LHRH stimulation testing for suspected precocious puberty between 01/01/2019 and 01/01/2024 * No written opposition to reuse of medical data Exclusion Criteria: * Written opposition to data reuse * Age \<4 years or \>11 years 11 months * LHRH test performed for indications other than suspected precocious puberty

Primary outcome measure(s)

  • Basal LH threshold for diagnosis of central precocious puberty — At time of diagnostic evaluation (retrospective data from 2019-2024)
    Determination of the basal LH level associated with a positive diagnosis of central precocious puberty (LH peak \>5 IU/L) and estimation of the number of LHRH stimulation tests that could have been avoided using this threshold.

Trial sites (1)

FacilityCityRegionStatus
Service de Pédiatrie 1 - CHU de Strasbourg - France Strasbourg France Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07864116 on ClinicalTrials.gov ↗ ← All trials in France