Dynamical Electrophysiology and Neuropathology in Lewy's Bodies Disease

Condition(s) studied

Study summary

Lewy body disease (LBD) is a neurodegenerative disorder that causes cognitive and behavioral problems. However, it is difficult to diagnose, and its pathophysiology is still not fully understood. The usual diagnostic criteria for LBD have excellent specificity but poor sensitivity. In particular, we lack paraclinical tests that can make a significant contribution. LBD patients may exhibit abnormalities in brain activity dynamics, which can be detected by EEG and may be linked to neuronal dysfunctions specific to the disease. The objective of this study is twofold: first, to assess the validity of this observation, that is, to confirm that the observed phenomenon is indeed linked to the pathophysiology of LBD, and second, to clarify the nature of these abnormalities by exploring the brain dynamics of LBD patients in greater detail.

Eligibility

Primary outcome measure(s)

• Parameter θ of dynamic fluidity of brain activity — Up to 12 months
  Parameter θ of dynamic fluidity of brain activity (quantifying the system's ability to move away from its current configuration) θ is used to measure something specific in the brain: how flexible its activity is. Quantifying the system's ability to move away from its current configuration: * In plain words, θ tells us how much the brain can change from its current state. * High θ → brain is very flexible, can switch between states easily. * Low θ → brain is rigid, stays in the same pattern longer.

Trial sites (1)

More University Hospital, Strasbourg, France trials in France

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