Impact of Extrarenal Myoglobin Clearance on Renal Recovery in Patients With Severe Rhabdomyolysis

Condition(s) studied

Study summary

Severe rhabdomyolysis is a common medical emergency that can lead to acute kidney injury (AKI), sometimes requiring extracorporeal renal replacement therapy (ECRT). Myoglobin plays a major role among the molecules involved in nephrotoxicity. While ECRT techniques are commonly used in this situation, their actual effectiveness in eliminating myoglobin and improving renal function remains poorly established. In particular, mid-cut-off membranes, developed to better remove intermediate molecular weight molecules, could improve renal prognosis. This study aims to evaluate, using retrospective clinical data, the impact of these techniques on renal recovery.

Eligibility

Primary outcome measure(s)

• Total duration of dependence on extrarenal purification (ERP) (in days) — up to 15 month
  Total duration of dependence on ERC (in days), defined as the number of days between initiation and discontinuation of any form of dialysis.

Trial sites (1)

More University Hospital, Strasbourg, France trials in France