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Starting soon Not applicable

Assesment of Epidural Platelet-Rich Plasma (PRP) Injection During Uniportal Endoscopic Lumbar Disc Herniation Excision on Residual Neuropathies

NCT07770750 · tracked via the Priya Life Science France tracker
Phase
Not applicable
Started
2026-09-01
Last updated
2026-08-20

Condition(s) studied

Lumbar Herniated Disc

Investigational drug(s) / intervention(s)

Uniportal endoscopic lumbar disc herniation removal

Uniportal endoscopic lumbar disc herniation removal: PRP is obtained from the patient's own blood, prepared, and subsequently reinjected into the patient at the end of uniportal endoscopic lumbar disc herniation removal.

Study summary

The aim of this study is to assess neuropathic pain in the lower limb at 6 months post-operation in patients who have undergone surgery for a lumbar disc herniation using single-port endoscopic discectomy combined with an epidural PRP injection.

This study is based on the hypothesis that intraoperative epidural administration of PRP during discectomy may improve healing, reduce nerve inflammation and potentially minimise post-operative pain and complications.

Participants will perform an epidural PRP injection and questionnaires as part of this research.

Eligibility

Sex
ALL
Min age
18 Years
Max age
55 Years
Healthy volunteers
No
Inclusion Criteria: * Patients, male or female, aged ≥ 18 and ≤ 55 * Patients with a diagnosis of a single-level lumbar disc herniation confirmed by MRI * Patients in whom conservative treatment has failed for at least 6 weeks * Patients for whom monoportal endoscopic lumbar disc herniation excision is indicated * Patients with lower-limb radicular pain of an intensity ≥ 3/10 on the Numerical Pain Scale * Patients affiliated with or covered by a social security scheme * French-speaking patients who have signed an informed consent form Exclusion Criteria: * Patients with a history of lumbar spine surgery or epidural injection * Patients with progressive neurological deficits or cauda equina syndrome * Patients with coagulopathy or systemic hematological disorders * Patients with an active infection or autoimmune disease * Patients with multilevel disc herniation or concomitant cervical spine pathology * Patients with scoliosis \> 40°. * Patients already enrolled in another clinical study * Protected patients: adults under guardianship, curatorship, or other legal protection measures; patients deprived of liberty by judicial or administrative decision * Patients hospitalized without consent * Patients receiving psychiatric care * Patients unable to provide informed consent. * Pregnant or breastfeeding women, including parturient women

Primary outcome measure(s)

  • Presence of neuropathic pain — At 6 months follow-up
    Neuropathic pain will be assessed with DN-4 questionnaire. If the score is 4 or higher, the test is considered positive (0 is the minimum value, 10 the maximum value (the worst pain)).

Trial sites (1)

FacilityCityRegionStatus
Hôpital Privé Jean Mermoz Lyon France
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07770750 on ClinicalTrials.gov ↗ ← All trials in France