24 hours antibiotics: Antibiotic therapy will start 24 hours before urological surgery
48 hours antibiotics: Antibiotic therapy will start 48 hours before urological surgery
Study summary
Endourology poses the problem of post-operative infections. The need to obtain a negative urine culture prior to surgery is accepted, and the effectiveness of this measure in reducing the risk of post-operative infection has been proven.
Current French recommendations are unanimous in favour of preventive treatment for asymptomatic bacteriuria (positive urine culture) prior to urological procedures involving contact with urine. These same recommendations specify that treatment should be brief, with a preoperative course of antibiotics lasting 48 hours.
However, the scientific literature on the subject does not provide an answer to the question of whether 48 hours is the optimal duration of preoperative antibiotic treatment to avoid the risk of postoperative infection.
In this context, it is interesting to evaluate a duration of preoperative antibiotic therapy limited to 24 hours, as no study can confirm that 24 hours of treatment is insufficient to prevent post-operative infection.
Eligibility
Sex
MALE
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Patients over 18 years of age
* Patients scheduled for urological endoscopy for one of the following indications: endoscopic surgery of the upper urinary tract (diagnostic, for treatment of stones or ureteral strictures), endoscopic prostate surgery (with or without laser: enucleation, vaporisation, resection), endoscopic surgery of the bladder and urethra (particularly tumours, strictures and foreign bodies) and ureteral stent surgery
* Patients with a positive preoperative urine culture (presence of bacteria at more than 103/mL)
* Asymptomatic patients (no signs of urinary tract infection in particular)
* Patients affiliated with or covered by a social security scheme
* French-speaking patients who have signed an informed consent form
Exclusion Criteria:
* Patient participating in another clinical trial
* Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision
* Patient with an immune deficiency
* Patient presenting symptoms of preoperative pyelonephritis (fever)
Primary outcome measure(s)
Post-operative infectious complications. — One month Post-operative infectious complications will be assessed as %. Post-operative infection will be defined as:
• A fever (T\>38°C) / hypothermia (T\<36°C) with no other cause other than urological, OR lower back pain, OR lower urinary tract symptoms that appeared or persisted at least 7 days after the procedure.
AND
• A positive urine culture (leukocyturia \>or= 10\^4/ml and positive urine culture \>10\^3 cfu/ml for a uropathogen)
Trial sites (1)
Facility
City
Region
Status
Hôpital Privé des Peupliers
Paris
France
More GCS Ramsay Santé pour l'Enseignement et la Recherche trials in France
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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