Platelet Serotonin Deficiencies: the Strasbourg Experience

Condition(s) studied

Study summary

Hemorrhagic syndromes are investigated using algorithms established by reference centers and hemostasis societies.

The investigation of platelet dense granules (nucleotide and serotonin testing) is part of the second-line tests.

It can be performed in cases of platelet aggregation abnormalities in platelet-rich plasma (PRP) suggesting a secretion abnormality, or in cases where the latter is normal, it can be performed if the patient's clinical presentation points to a primary hemostasis abnormality and the clinician wishes to pursue further investigations Intraplatelet serotonin deficiencies are often iatrogenic and may be accompanied by bleeding.

Their impact on platelet function is poorly documented.

Eligibility

Primary outcome measure(s)

• Score of ISTH BAT Hemorrhagic Questionnaire — Up to 12 months
  ISTH BAT bleeding questionnaire with its 12-item grid scored from 0 to 4: A score ≥ 4 in men or ≥ 6 in women makes the presence of a constitutional hemostasis disorder highly probable

Trial sites (1)

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