Testing the Interplay of Gambling, Emotion and Reward

Condition(s) studied

Investigational drug(s) / intervention(s)

fMRI: A brain imaging technique that measures in vivo the activity of brain areas by detecting local changes in blood flow.

Ecological Momentary Assessment: studies people's thoughts and behaviour in their daily lives by repeatedly collecting data in an individual's normal environment, at or close to the time they carry out that behaviour

Study summary

Background The nature and direction of dysfunctional reward processing in gambling disorder remains unclear. We aim to test a novel neurobiological model of gambling addiction, that takes into account inter-individual differences, as well as the multifactorial nature of gaming addiction.

Objectives

Primary objective:

This project will test the hypothesis that there are two opposite brain phenotypes that characterize two distinct subpopulations of gamblers, so-called impulsive vs. emotional, respectively.

Secondary objective:

This project will also seek to determine whether the brain phenotypes proposed above are capable of predicting gambling behavior outside the laboratory.

Study design The primary objective will be tested using a reward task and a facial emotion recognition task performed by participants in an fMRI scanner.

The secondary objective will be tested by combining fMRI measures with behavioral measures from everyday life collected via Ecological Momentary Assessment (EMA).

Study population This study will focus on individuals with gambling problems, as well healthy subjects with no gambling problems and no psychiatric comorbidities.

Outcomes/Endpoints

Primary endpoint:

We will compare striatum and amygdala reactivity between the three groups of impulsive gamblers, emotional gamblers and healthy subjects.

Secondary endpoint:

We will assess the correlation between emotional states and gambling behavior in everyday life, based on striatum and amygdala reactivity, using multiple linear regression models.

Eligibility

Primary outcome measure(s)

• Striatal BOLD response to reward outcomes and amygdala BOLD response to emotional stimuli — 4 weeks
  Striatal BOLD response: average BOLD signal as measured with fMRI in the striatum in response to monetary reward outcomes in a gambling task. amygdala BOLD response: average BOLD signal as measured with fMRI in the amygdala in response to emotional faces in a facial emotion recognition task.

Trial sites (1)

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