People Bereaved by Violent Death : Negative Event Biases and Temporal Perception

NCT05874362 · tracked via the Priya Life Science France tracker

Sponsor

Hôpital le Vinatier

Phase

Not applicable

Started

2023-09-19

Last updated

2026-06-12

Condition(s) studied

Post Traumatic Stress Disorder

Investigational drug(s) / intervention(s)

Diagnosis of depressive episode or post traumatic stress disorderNo diagnosis of depressive episode or post traumatic stress disorder

Diagnosis of depressive episode or post traumatic stress disorder: Clinical diagnosis of depressive episode or post traumatic stress disorder, confirmed

No diagnosis of depressive episode or post traumatic stress disorder: No elements in clinical assessment for the diagnosis of a depressive episode or post traumatic stress disorder

Study summary

A violent death is defined by its brutality, unexpectedness and is secondary to an external cause (suicide, homicide, accident). Bereavement following a violent death constitutes a particular clinical situation, at risk of complications. Research on bereavement after a violent death shows higher risks of psychiatric and somatic complications than in bereavement by non-violent death. These complications, sometimes comorbid, take the form of depressive episodes, post-traumatic stress disorders, suicidal behavior and prolonged grief disorders after 12 months, precociously mediated by ruminations.

Processes responsible for this increased risk of complications are poorly documented. Current literature relates mainly to socio-demographic and epidemiological factors which, alone, do not explain this difference in risks. Further research is needed exploring other kinds of data and processes. To our knowledge, there is no description of early neurocognitive functioning in people bereaved after violent death. This study aims at exploring early neurocognitive processes which can lead to complications in people bereaved by violent death.

Eligibility

Sex

ALL

Min age

18 Years

Max age

65 Years

Healthy volunteers

Inclusion Criteria: * An age between 18 and 65 years old * Recent bereavement by violent death of a relative in first and second degree Exclusion Criteria: * Protected adults * Lack of mastering French language * History of neurodegenerative disorder * History of psychiatric disorder treated pharmacologically with modification of the basic treatment in the month preceding the death * The take of an benzodiazepine treatment in the 24th hours before the first visit (T0)

Primary outcome measure(s)

Amplitude of the Late Positive Potential (LPP) component in unpredictable event condition — Between Day15 and Day30 after the death of one's loved one
Measure in Electroencephalography (EEG) of the Late Positive Potential (LPP), an Event Related Potential (ERP) relating to attention biases

Trial sites (1)

Facility	City	Region	Status
Hopital Vinatier	Bron	France	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT05874362 on ClinicalTrials.gov ↗ ← All trials in France