Polynucleotide-Hyaluronic Acid Gel With Xenograft for Alveolar Ridge Preservation

Condition(s) studied

Investigational drug(s) / intervention(s)

Polynucleotide-Hyaluronic Acid Gel With Xenograft: Xenograft mixed with polynucleotide-hyaluronic acid gel and covered with a collagen membrane for alveolar ridge preservation after tooth extraction.

Xenograft With Collagen Membrane: Xenograft placed in the extraction socket and covered with a collagen membrane for alveolar ridge preservation after tooth extraction.

Study summary

This randomized controlled clinical trial will evaluate the efficacy of polynucleotide-hyaluronic acid gel combined with xenograft and collagen membrane for alveolar ridge preservation following tooth extraction. Twenty participants will be randomly allocated into two parallel groups. The test group will receive xenograft mixed with polynucleotide-hyaluronic acid gel and covered with a collagen membrane, while the control group will receive xenograft with a collagen membrane alone. Clinical and CBCT assessments will be performed at baseline and during follow-up. After 6 months, ridge dimensional changes will be evaluated and core biopsies will be obtained at the time of implant placement for histological assessment.

Eligibility

Primary outcome measure(s)

• Change in Buccal Bone Plate Height — Baseline and 6 months
  The height of the buccal bone plate will be measured using digital superimposition of Cone Beam Computed Tomography (CBCT) scans obtained at baseline and 6 months. Measurements will be recorded in millimeters

Trial sites (1)

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