Caffeine and Prophylactic Noradrenaline Requirement During Cesarean Delivery

Condition(s) studied

Investigational drug(s) / intervention(s)

Caffeine (200 mg): Patients will receive 200 mg oral caffeine 30 minutes before spinal anesthesia

Placebo: Patient will receive placebo capsule

Study summary

Spinal anesthesia is the preferred regional technique in obstetric practice because it provides high maternal satisfaction and eliminates the need for airway manipulation. Despite these advantages, it is frequently complicated by spinal anesthesia-induced hypotension , defined as a reduction in systolic blood pressure of more than 20% from baseline or an absolute SBP below 100 mmHg. Spinal hypotension can have serious consequences, including maternal hypoperfusion that may lead to neurological or renal dysfunction, as well as fetal acidosis and bradycardia, which can compromise neonatal outcomes. The present study aims to evaluate the effect of preoperative caffeine administration on noradrenaline requirements during spinal anesthesia in obstetric patients. Specifically, the objectives are to compare noradrenaline requirements between the study groups and to assess the incidence of hypotension in both groups.

Eligibility

Primary outcome measure(s)

• Average noradrenaline requirement — After spinal anesthesia till delivery
  The total noradrenaline administered as an infusion plus boluses divided by patient weight and infusion time.

Trial sites (1)

More Cairo University trials in Egypt

Other trials for the same condition