Observational Study About the Use of Perfusion Index to Use Vasopressor in Sepsis

NCT06860438 · tracked via the Priya Life Science Egypt tracker

Sponsor

Ain Shams University

Phase

Observational

Started

2024-08-01

Last updated

2025-03-06

Condition(s) studied

SepsisPerfusion IndexVasopressor

Investigational drug(s) / intervention(s)

Vasoconstrictor Agents

Vasoconstrictor Agents: vasopressor agents will be started in patients with sepsis who will not improved using the resuscitation fluids

Study summary

In this thesis we will use the current state of knowledge that PI can provide a reliable information about the state of peripheral microcirculation during the state of sepsis and septic shock in ICU patients and that can interfere with the timing of starting vasopressor treatment in sepsis and septic shock

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: \- All ICU patients with clinically suspected sepsis and septic shock ( signs include fever hypotension oliguria and confusion combined with culture results showing infection .Septic shock is a subset of sepsis involves persistent hypotension (mean arterial pressure ≥ 65 mm Hg, and a serum lactate level \> 18 mg/dL \[2 mmol/L)not responding to fluid resuscitation ) . Exclusion Criteria: * Pregnant females * Patients on vasopressor or positive inotropic drugs * Patients with hypothermia (defined as central temperature \<35°C). * Patient with impairment of upper extremity circulation,(such as those who underwent radial artery harvesting for coronary artery bypass grafting or had suspected occlusion of the radial artery prior to surgery,) * Patients had undergone an operation that involved the large arteries of the aortic arch. * Patients with atherosclerosis .

Primary outcome measure(s)

PI (perfusion index ) variable will be measured at the start of resuscitation and at the start of vasopressor therapy — PI variable will be recorded at baseline( T0 )and after 5 minutes from starting of resuscitation (T5) and then 6 hours thereafter for 24 hours
PI will be measured at the start of resuscitation after volume resuscitation and before the use of vasopressor then will be measured 6 hours after resuscitation

Trial sites (1)

Facility	City	Region	Status
faculty of medicine Ain Shams University	Cairo	Egypt	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06860438 on ClinicalTrials.gov ↗ ← All trials in Egypt