The Link Between Periodontitis, Smoking and Oral Cancer

Condition(s) studied

Investigational drug(s) / intervention(s)

biopsy for oral cancer: surgical biopsy is to be taken for diagnosis of oral cancer or premalignant lesions

periodontal examination: Periodontal clinical examination to all by periodontal charting

Study summary

Periodontitis is a widely prevalent disease worldwide that has serious public health consequences. Its prognosis includes tooth loss and edentulism, a condition that negatively affects chewing causing functional disability; and esthetics causing social impairment. Consequently, periodontitis may end up causing marked impairment of the quality of life of the affected patients, impairment of general health and increasing the dental care costs significantly.

Changes in the oral mucosa arise by primary products resulting from tissue breakdown due to gingivitis. It then triggers the host cells to produce proteinases that mediate loss of marginal periodontal ligaments, apical migration of the junctional epithelium and apical spread of bacterial biofilm.

Therefore, this research aims to identify the risk of smoking to both periodontitis and oral cancer, and the risk of periodontitis to oral cancer.

Eligibility

Primary outcome measure(s)

• Periodontitis — the 10 years of the study
  arising of periodontitis or increase in the grade of an already existing case of periodontitis

Trial sites (1)

More Cairo University trials in Egypt

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