Injectable Platelet-Rich Fibrin With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defects

NCT07613606 · tracked via the Priya Life Science Egypt tracker

Sponsor

October 6 University

Phase

Not applicable

Started

2026-03-01

Last updated

2026-05-29

Condition(s) studied

Platelet-Rich FibrinMinimally Invasive Non-Surgical TechniquePeriodontal Intrabony Defects

Investigational drug(s) / intervention(s)

Minimally invasive non-Surgical techniqueMinimally invasive non-Surgical technique + platelet-rich fibrin

Minimally invasive non-Surgical technique: Patients will receive minimally invasive non-Surgical technique (MINST) alone

Minimally invasive non-Surgical technique + platelet-rich fibrin: Patients will receive minimally invasive non-Surgical technique (MINST)+ injectable platelet-rich fibrin (i-PRF) injection

Study summary

This study aims to clinically and radiographically evaluate the adjunctive effect of injectable platelet-rich fibrin (i-PRF) used in combination with a minimally invasive non-surgical technique for the regenerative treatment of intrabony periodontal defects.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Patients of both genders \>18 years old, medically free of systemic diseases affecting periodontal regeneration. * Diagnosis of 'periodontitis' stage III (grades B or C). * Single-rooted and multi-rooted vital teeth in either the maxilla or the mandible. * Presence of comparable bilateral two- or three-walled intrabony defects \[probing pocket depth (PPD), \> 5 mm with intrabony defect depth ≥ 3 mm, from the alveolar crest to the defect base, at screening radiograph\] not in a furcation-involved tooth. Exclusion Criteria: * Patients with systemic illness known to affect the outcome of periodontal therapy, including diabetes, immune deficiencies, etc. * Pregnant and lactating women * Current use of any form of tobacco. * Non-surgical periodontal treatment in the past 6 months, or surgical periodontal treatment in the past 12 months. * Degree 2 or 3 mobility of the involved sites.6. * Presence of periapical pathology, acute infection, or subgingival restoration which could interfere with clinical measurements.

Primary outcome measure(s)

Presence of comparable bilateral-walled intrabony defects — 6 months postoperatively
Assessment of intrabony defect fill radiographically will be measured using the standardized paralleling technique. Presence of comparable bilateral-walled intrabony defects (PPD, \> 5 mm with intrabony defect depth ≥ 3 mm, from the alveolar crest to the defect base, at screening radiograph) not in a furcation-involved tooth.

Trial sites (1)

Facility	City	Region	Status
October 6 University	Cairo	Egypt	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07613606 on ClinicalTrials.gov ↗ ← All trials in Egypt