Effect of Neuromuscular Electrical Stimulation on Muscle Mass in ECMO Patients

Condition(s) studied

Investigational drug(s) / intervention(s)

NMES: NMES will be applied bilaterally to the quadriceps femoris muscles (rectus femoris and vastus intermedius) for 30 minutes daily for one week. Stimulation parameters will include a frequency of 50 pulses per second, pulse duration of 1000 microseconds, ramp time of 5 seconds, and a duty cycle of 1:5. Two rectangular carbon electrodes (6 × 8 cm) will be placed over the motor points of the targeted muscles. Patients will be positioned in supine lying with approximately 40 degrees knee flexion. In addition, participants will receive a conventional physiotherapy program twice daily, including passive and active-assisted range of motion exercises, early mobilization, bed mobility, sitting, standing, and ambulation.

Conventional physiothrapy program: Participants in this group will receive a conventional physiotherapy program only during extracorporeal membrane oxygenation (ECMO) support. The program will be administered twice daily for one week. The intervention will include early mobilization strategies starting with passive range of motion exercises and progressing to active-assisted and active exercises as tolerated. Rehabilitation activities will include bed mobility, sitting at the edge of the bed, bedside standing, and assisted ambulation according to patient tolerance and clinical stability. All interventions will be delivered according to standard ICU physiotherapy practices. Neuromuscular electrical stimulation (NMES) will not be applied in this group.

Study summary

The goal of this clinical trial study: is to determine the effectiveness of neuromuscular electrical stimulation in critically ill patients undergoing extracorporeal membrane oxygenation.

The main questions it aims to answer are:

* Does NMES has an effect when added to conventional protocol for ECMO patients?
* Does NMES will help in preserve muscle mass?
* Patients will recieve the treatment untill discharge.
* Assesment will be done before and after treatement

Eligibility

Primary outcome measure(s)

• Change in quadriceps muscle mass — Baseline and after 7 days of intervention
  Quadriceps muscle mass will be assessed using ultrasonography by measuring muscle thickness and/or cross-sectional area of the rectus femoris muscle. Measurements will be performed at baseline (before intervention) and after one week of intervention during ECMO support. The primary endpoint will be the change in muscle mass over time between groups.

Trial sites (1)

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