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Clinical Trials in Egypt / NCT07379710
Recruiting Phase 4

Norepinephrine With Ephedrine Versus Norepinephrine Alone During Spinal Anesthesia for Cesarean Delivery

NCT07379710 · tracked via the Priya Life Science Egypt tracker
Sponsor
Cairo University
Phase
Phase 4
Started
2026-06-01
Last updated
2026-10-21

Condition(s) studied

Incidence of Post-spinal Hypotension

Investigational drug(s) / intervention(s)

Ephedrine and Norepinephrine infusionNorepinephrine infusion →

Ephedrine and Norepinephrine infusion: Ephedrine 10 mg (2.5mg/ml) direct I.V will be given simultaneous with Norepinephrine infusion 0.08 mcg/kg/min

Norepinephrine infusion: 4 ml normal saline direct I.V will be given simultaneous with norepinephrine (to keep blinding) Infusion 0.08 mcg/kg/min only be infused

Study summary

We hypothesize that the addition of ephedrine to norepinephrine infusion could decrease the incidence of post spinal hypotension(PSH) in parturient undergoing C.S under spinal anesthesia and minimize the changes in heart rate

Eligibility

Sex
FEMALE
Min age
18 Years
Max age
40 Years
Healthy volunteers
No
Inclusion Criteria: * ASA physical status II * Age: 18 to 40 years * Undergoing Elective Lower Segment Cesarean Section under Spinal Anesthesia. Exclusion Criteria: * Uncontrolled cardiac morbidities As reduction of ejection fraction\< 60%, History (within 3months) of myocardial infarction, cerebrovascular accident, transient ischemic attacks or coronary artery disease/stents * Poorly controlled Hypertensive disorders of pregnancy * Peripartum bleeding * Coagulation disorders * Baseline systolic blood pressure (SBP) \< 100 mmHg * Refusal of patients.

Primary outcome measure(s)

  • Incidence of post-spinal hypotension — Baseline (T0), just after spinal anaesthesia (T1) then every 2.5 minutes until delivery of the fetus

Trial sites (1)

FacilityCityRegionStatus
Faculty of Medicine, Cairo University, Cairo Cairo Egypt Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07379710 on ClinicalTrials.gov ↗ ← All trials in Egypt