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Clinical Trials in Egypt / NCT06777303
Active, not recruiting Not applicable

Efficacy of Nano-Curcumin and Nano-Hyaluronic Acid as an Adjunct to Scaling and Root Planing in the Treatment of Periodontitis

NCT06777303 · tracked via the Priya Life Science Egypt tracker
Sponsor
Mansoura University
Phase
Not applicable
Started
2024-06-02
Last updated
2025-05-20

Condition(s) studied

Periodontitis

Investigational drug(s) / intervention(s)

curcurmin loaded on chitosan nano-particleshyaluronic acid loaded on chitosan nano-particlesscaling and root planningchitosan nano-particles

curcurmin loaded on chitosan nano-particles: the formulation of curcumin and incorprating it with chitosan nano-particles will increase the absorption rate in the gingival sulcus

hyaluronic acid loaded on chitosan nano-particles: the formulation of hyaluronic acid and incorprating it with chitosan nano-particles will increase the absorption rate in the gingival sulcus

scaling and root planning: the -ve control group in the study

chitosan nano-particles: the +ve control group in the study

Study summary

to evaluate Efficacy of Locally Applied Nano-Curcumin and Nano-Hyaluronic Acid as an Adjunct to Scaling and Root Planing in the Treatment of Periodontitis patients

Materials and methods: forty patients (n=40) were selected from the Department of Oral Medicine and Periodontology, Faculty of Dentistry, Mansoura University, The participants forty patients are classified into four groups:

* Group1 : (-ve control group): SRP alone
* Group2: (+ve control group): SRP+ chitosan Nano-particles
* Group3: SRP + Curcumin-coated chitosan Nano-particles
* Group4: SRP+ hyaluronic acid -coated chitosan Nano-particle

All Patients will undergo Phase I therapy, which includes scaling and root planing using ultrasonic tips and gracey curettes. Additionally, mechanical oral hygiene instructions will be provided, and participants will be advised to refrain from using any mouthwash throughout the duration of the study.

Furthermore, patients within groups 2 to 4 will be subjected to an extra measure involving the application of the respective gel associated with their designated group. The gel will be administered on a weekly basis for duration of five weeks.

Clinical indices (plaque index (PI), gingival index (GI), clinical attachment level (CAL), and probing depth (PD)). Laboratory assessment will be done at baseline and final assessment( after 3 months) . tess will be for antioxdiant levels and TNF alpha

* Total anti-oxidant capacity(T-AOC) using Assay kit50T
* TNF alpha using ELISA Kit (96T)

Eligibility

Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Patients who are systemically healthy * Patient exhibiting periodontal pocket depths (PD) ≤5mm * presence of clinical attachment loss (CAL) between 1-4mm * cooperative individuals capable of adhering to mechanical oral hygiene instructions * Patients who agreed on both written and verbal consent to participate in the study. Exclusion Criteria: * patients with recent history of periodontal treatment (within the last 3 months) * patients with recent use of antibiotic (within the past 3 months) * pregnant or lactating women, * individuals who are malnourished and taking vitamin supplements, * Patients who regularly use mouthwashes.

Primary outcome measure(s)

  • Probing pocket depth reduction — 12 weeks
    pocket depth is calculated using a UNC 15 perio probe to calculate the distance between the base of the pocket to the free gingival margin

Trial sites (1)

FacilityCityRegionStatus
Mansoura university Al Mansurah Dakahlia Governorate

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06777303 on ClinicalTrials.gov ↗ ← All trials in Egypt