Role of HFNC During FOB in Patients With Respiratory Failure

NCT07880964 · tracked via the Priya Life Science Egypt tracker

Sponsor

Mansoura University

Phase

Not applicable

Started

2026-04-12

Last updated

2026-10-19

Condition(s) studied

Respiratory FailureRespiratory Failure With Hypercapnia

Investigational drug(s) / intervention(s)

High flow nasal canula

High flow nasal canula: High-flow nasal cannula (HFNC) oxygen therapy will be administered using the Vapotherm Precision Flow Hi-VNI system. HFNC will be initiated approximately 10 minutes before fiber-optic bronchoscopy, maintained throughout the procedure, and continued for 1-2 hours after the procedure. The initial flow rate will be 40 L/min and may be adjusted between 10 and 40 L/min according to clinical requirements. FiO2 will be titrated to maintain the predefined oxygen saturation target (SpO2 ≥95% in most patients and 88-92% in patients with type 2 respiratory failure). Gas temperature will be set at approximately 34°C with 100% relative humidity. Continuous monitoring of SpO2, heart rate, respiratory rate, and blood pressure will be performed during the procedure, with additional arterial blood gas and end-tidal CO2 assessment according to the study protocol.

Study summary

This prospective interventional study aims to evaluate the safety and efficacy of high-flow nasal cannula (HFNC) oxygen therapy during fiber-optic bronchoscopy in patients with respiratory failure. The study will assess oxygenation, ventilation, , procedural interruptions, adverse events, patient comfort, and clinical outcomes during and after bronchoscopy.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: Participants will be eligible for inclusion if they meet all of the following criteria: 1. Adult patients undergoing clinically indicated fiber-optic bronchoscopy. 2. Patients with respiratory failure requiring supplemental oxygen or respiratory support. 3. Patients who provide written informed consent to participate in the study. Exclusion Criteria: * Participants will be excluded if they meet any of the following criteria: 1. Patients requiring immediate endotracheal intubation or invasive mechanical ventilation before bronchoscopy. 2. Patients with severe or refractory hypoxemia despite maximal non-invasive oxygen/respiratory support before the procedure. 3. Hemodynamic instability that precludes safe fiber-optic bronchoscopy. 4. Patients with contraindications to fiber-optic bronchoscopy or to the planned bronchoscopy procedure. 5. Patients who refuse or withdraw informed consent. 6. Patients in whom HFNC cannot be safely applied or tolerated.

Primary outcome measure(s)

Change in PaO₂/FiO₂ ratio: Change in the arterial oxygen partial pressure to inspired oxygen fraction ratio (PaO₂/FiO₂) — From baseline before fiber-optic bronchoscopy to 2 hours after completion of the procedure.
The PaO₂/FiO₂ ratio will be assessed using arterial blood gas analysis to evaluate changes in oxygenation in patients receiving high-flow nasal cannula (HFNC) during fiber-optic bronchoscopy. Arterial blood samples will be collected at baseline before the procedure and 2 hours after its completion while participants are receiving HFNC
Change in PaCO₂: Change in arterial partial pressure of carbon dioxide (PaCO₂) from baseline before fiber-optic bronchoscopy to 2 hours after completion of the procedure. — From baseline before fiber-optic bronchoscopy to 2 hours after completion of the procedure.
PaCO₂ will be measured using arterial blood gas analysis (mmHg) to assess changes in ventilation in patients receiving HFNC during fiber-optic bronchoscopy. Arterial blood samples will be collected at baseline before the procedure and 2 hours after its completion while participants are receiving HFNC

Trial sites (1)

Facility	City	Region	Status
Faculty of Medicine, Mansoura University	Al Mansurah	Dakahlia Governorate	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07880964 on ClinicalTrials.gov ↗ ← All trials in Egypt