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Clinical Trials in Egypt / NCT06755372
Recruiting Observational

The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population

NCT06755372 · tracked via the Priya Life Science Egypt tracker
Sponsor
Ain Shams University
Phase
Observational
Started
2025-04-01
Last updated
2025-07-04

Condition(s) studied

PeriodontitisEnd-stage Renal Disease

Study summary

Chronic kidney disease (CKD) is a significant public health issue in Egypt, leading to end-stage renal disease (ESRD). ESRD patients often suffer from oral abnormalities due to the disease and medications. Periodontitis is linked to systemic diseases, including renal disease, with inflammation playing a key role. TLR4 genetic variations may influence susceptibility to CKD and periodontitis. This study investigates the association between TLR4 \[Gly/Thr (rs2149356)\] polymorphism and chronic periodontal disease in ESRD patients in Egypt.

Eligibility

Sex
ALL
Min age
30 Years
Max age
60 Years
Healthy volunteers
Accepted
Group I: Healthy Subjects with Periodontitis Inclusion Criteria: Age: 30 to 60 years Gender: Both male and female Diagnosed with Periodontitis stage II and/or stage III Systemically healthy, no history of systemic diseases Not on long-term medications Exclusion Criteria: Smokers Individuals with any systemic disease or long-term medication use Group II: ESRD Patients with Periodontitis Inclusion Criteria: Age: 30 to 60 years Gender: Both male and female Diagnosed with end-stage renal disease (ESRD) on regular hemodialysis Diagnosed with Periodontitis stage II and/or stage III Unrelated Egyptians from a similar socioeconomic status, residing in the same geographical area Underlying type 2 diabetes mellitus Exclusion Criteria: Individuals with kidney transplants Individuals with systemic diseases other than diabetes History of malignancy Smokers

Primary outcome measure(s)

  • Clinical Attachment Level (CAL): — single point "Baseline"
    Description: The CAL measures the extent of periodontal support around a tooth, from the cementoenamel junction (CEJ) to the base of the pocket, crucial for diagnosing periodontal disease. Measurement Method: CAL is recorded using a periodontal probe by measuring probing depth (PD) and distance from the gingival margin to the CEJ. CAL is calculated as follows: CEJ at gingival margin: CAL = PD Gingival margin coronal to CEJ: CAL = PD - Distance from Gingival Margin to CEJ Gingival margin apical to CEJ: CAL = PD + Distance from CEJ to Gingival Margin in non- periodontitis individuals CAL is zero

Trial sites (1)

FacilityCityRegionStatus
hemodialysis center at Benha University Hospital. Al Fayyum Faiyum Governorate Recruiting

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Other trials for the same condition

Effect of Nano-Hyaluronic Acid in Intrabony Defects Treated With Minimally Invasive Non-Surgical Technique Active, not recruiting
Clinical Evaluation of Nano-Hydroxyapatite as an Adjunctive to Minimally Invasive Non-Surgical Technique in the Treatment of Deep Intra-bony Defects Active, not recruiting
Therapeutic Effect of Manuka Honey Oral Rinse in Periodontitis Patients Undergoing Hemodialysis Recruiting
Efficacy of Nano-Curcumin and Nano-Hyaluronic Acid as an Adjunct to Scaling and Root Planing in the Treatment of Periodontitis Active, not recruiting
Comparative Evaluation of the Effect of Different Adjunctive Air Polishing Powders in Nonsurgical Periodontal Therapy in Patients with Stage II and III Periodontitis Enrolling by invitation
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06755372 on ClinicalTrials.gov ↗ ← All trials in Egypt