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Clinical Trials in Denmark / NCT07607977
Recruiting Observational

Exploring Biomarkers in the Heat and Moisture Exchange Filters

NCT07607977 · tracked via the Priya Life Science Denmark tracker
Sponsor
Aalborg University Hospital
Phase
Observational
Started
2026-05-08
Last updated
2026-05-27

Condition(s) studied

Respiratory Inflammation

Study summary

When patients undergo major surgery, they are connected to a ventilator during anesthesia. A heat and moisture exchange filter (HME filter) is routinely placed in the ventilator tubing to ensure that the inhaled air is warm and humidified. Today, HME filters are used routinely in all ventilator treatments. They are typically replaced once a day and discarded as regular waste after use.

The purpose of this study is to investigate whether HME filters contain proteins and small biological particles from the patient's exhaled air.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * ≥18 years, able to understand study information in Danish. * Admitted for elective surgery for non-malignant conditions with either intravenous or inhalation anaesthesia and invasive mechanical ventilation according to standard practice. * Expected invasive mechanical ventilation \> 1 hour. * Possess legal capacity. * Informed, signed consent is obtained. Exclusion Criteria: * Patients who are transferred to the ICU for continuous invasive mechanical ventilation after end of elective surgery. * Known chronic lung disease.

Primary outcome measure(s)

  • Total endogenous protein amount captured in HME filters measured by standard biochemical assays. — Through study completion, an average of 3 months.
    Quantification of the total amount of endogenous proteins recovered from heat moisture exchange (HME) filters using Biuret based analysis.

Trial sites (1)

FacilityCityRegionStatus
Aalborg University Hospital Gistrup Denmark Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07607977 on ClinicalTrials.gov ↗ ← All trials in Denmark