Coronary Computed Tomography Versus Invasive Angiography for Non-ST Elevation Acute Coronary Syndrome

Condition(s) studied

Investigational drug(s) / intervention(s)

CCTA: Participants will be examined with CCTA during admission.

Conventional ICA: Patients will be examined with conventional standard-of-care ICA.

Team-based interventional triage: The CCTA will be discussed at a coronary CT-team conference to establish the treatment strategy and provide guidance for any necessary interventional procedure.

Study summary

Coronary computed tomography angiography (CCTA) is a widely accepted initial diagnostic test for individuals suspected of having chronic coronary syndromes. However, there is limited evidence supporting its use in the acute setting. So far, no large-scale randomized trial has examined the performance of CCTA as an alternative to invasive coronary angiography (ICA) in individuals with non-ST-segment elevation myocardial infarction (NSTEACS).

If CCTA were to replace ICA as a routine procedure for individuals with NSTEACS, it could reduce the risk of complications related to ICA, improve patient comfort, expedite decision-making, and reduce healthcare expenses and interhospital transfers.

Eligibility

Primary outcome measure(s)

• Number of participants with a combined endpoint of major adverse cardiac events — At 1 year.
  All-cause mortality, non-fatal myocardial infarction, hospitalization with refractory angina, or hospitalization with heart failure.

Trial sites (6)

More Copenhagen University Hospital, Rigshospitalet trials in Denmark

Other trials for the same condition