Immediate Versus Postponed Single Blastocyst Transfer in mNC-FET

NCT04748874 · tracked via the Priya Life Science Denmark tracker

Sponsor

Rigshospitalet, Denmark

Phase

Not applicable

Started

2021-04-01

Last updated

2025-04-08

Condition(s) studied

InfertilityIVF

Investigational drug(s) / intervention(s)

Immediate mNC-FET

Immediate mNC-FET: In the immediate arm, patients undergo mNC-FET in the menstrual cycle immediately following oocyte retrieval and failed fresh embryo transfer or freeze-all.

Study summary

The purpose of this randomized controlled trial is to investigate if immediate single blastocyst transfer (in the first menstrual cycle following oocyte retrieval) is non-inferior to standard postponed single blastocyst transfer (in the second or subsequent menstrual cycle following oocyte retrieval) in modified natural cycle frozen-thawed embryo transfer (mNC-FET) in terms of live birth rate.

Eligibility

Sex

FEMALE

Min age

18 Years

Max age

40 Years

Healthy volunteers

Inclusion Criteria: * Patients eligible for FET in a modified natural cycle * Regular menstrual cycle (23-35 days) * Vitrified day 5 or 6 blastocyst * Blastocyst Gardner score \> or = 3BB at the day of vitrification Exclusion Criteria: * Uterine malformations or presence of hydrosalpinx * Submucosal uterine myomas * Uterine polyps * Allergy to standard fertility medication * Contradiction to standard fertility medication * Male of female HIV, hepatitis B or C * Preimplantation Genetic Testing (PGT) in the fresh cycle * Severe OHSS during the fresh cycle (defined as need for ascites drainage and/or hospital admission) * Oocyte donation * Testicular sperm aspiration (TESA)

Primary outcome measure(s)

Live birth rate per randomized patient — One-year follow-up after a positive pregnancy test
Live birth rate in patients randomized to immediate versus postponed FET
Live birth rate per protocol — One-year follow-up after a positive pregnancy test
Live birth rate in patients randomized to immediate versus postponed FET minus dropouts

Trial sites (1)

Facility	City	Region	Status
Fertility department, Rigshospitalet	Copenhagen	Denmark

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04748874 on ClinicalTrials.gov ↗ ← All trials in Denmark