VIsualization of Coronary Artery Disease for Modification of RISK Factors

NCT06413641 · tracked via the Priya Life Science Denmark tracker

Sponsor

Aarhus University Hospital

Phase

Not applicable

Started

2024-03-12

Last updated

2026-05-06

Condition(s) studied

Coronary Artery DiseaseNon-Obstructive Coronary Atherosclerosis

Investigational drug(s) / intervention(s)

Follow up at general practiceConsultationVisualization of CTA images

Follow up at general practice: As described before

Consultation: As described before

Visualization of CTA images: As described before

Study summary

The VICAD-RISK study assesses if visualization of coronary CT angiography (CTA) images in participants with non-obstructive coronary artery disease will improve LDL lowering, reduce reporting of side effects by cholesterol lowering medications, and modify the coronary artery disease phenotype over 12 months.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * New diagnosis of nonobstructive coronary artery disease * No known coronary artery disease (no previous coronary revascularization) * Coronary Artery Disease Reporting and Data System (CAD-RADS) score 1-3 * LDL cholesterol \> 2.0 mmol/l * Life expectancy \>3 years * Signed informed consent Exclusion Criteria: * Post CTA test indication for invasive coronary angiography * Non-evaluable CTA exam * Obstructive coronary disease (One or more coronary stenosis ≥70%, left main \>40%) * Ongoing lipid lowering medical treatment (Patients already on lipid lowering medical therapy can be included if the treatment was initiated \<3 months before the time of the CTA test) * BMI \>40 * Renal insufficiency (eGFR \<40 ml/min) * Allergy to iodinated contrast media * Contraindications to statins (Active liver disease Child-Pugh A, B and C, excessive alcohol consumption) * Participation in a cardiac rehabilitation or lifestyle modification program * Pregnancy

Primary outcome measure(s)

Change in LDL cholesterol — 12 months
Assessed by measurement of LDL cholesterol level (mmol/L) in blood samples at baseline and 12 months follow-up

Trial sites (5)

Facility	City	Region
Gødstrup Hospital	Gødstrup	Jutland
Aalborg University Hospital	Aalborg	Denmark
Bjarne L Nørgaard	Aarhus	Denmark
Hospital of South West Jutland	Esbjerg	Denmark
Vejle Hospital	Vejle	Denmark

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06413641 on ClinicalTrials.gov ↗ ← All trials in Denmark