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Clinical Trials in China / NCT07903454
Recruiting Observational

Anterior Segment Anatomy Assessed by Swept-Source OCT in Ocular Surgery Patients

NCT07903454 · tracked via the Priya Life Science China tracker
Sponsor
Nanfang Hospital, Southern Medical University
Phase
Observational
Started
2026-05-01
Last updated
2026-10-29

Condition(s) studied

CataractPrimary Angle-Closure Glaucoma

Investigational drug(s) / intervention(s)

Ocular anatomical parameters will be measured using a swept-source optical coherence tomography (SS-OCT) device (CASIA2; Tomey Corporation, Nagoya, Japan). The imaging examination will be used to asse

Ocular anatomical parameters will be measured using a swept-source optical coherence tomography (SS-OCT) device (CASIA2; Tomey Corporation, Nagoya, Japan). The imaging examination will be used to asse: Ocular anatomical parameters will be assessed using a swept-source optical coherence tomography (SS-OCT) device (CASIA2; Tomey Corporation, Nagoya, Japan). This non-invasive imaging examination provides detailed visualization and quantitative measurements of anterior segment structures. The collected imaging data will be used to evaluate ocular anatomical characteristics and investigate their associations with relevant clinical factors in patients undergoing anterior segment surgery. Surgical treatment decisions will follow routine clinical practice and will not be assigned by the study protocol.

Study summary

This observational study aims to evaluate ocular anatomical parameters in patients undergoing anterior segment surgery using swept-source optical coherence tomography (SS-OCT).

Anterior segment surgery, including procedures involving the cornea, lens, and other anterior eye structures, may be associated with changes in ocular anatomy. SS-OCT is a non-invasive imaging technique that provides detailed images of the anterior structures of the eye and allows quantitative assessment of ocular anatomical parameters.

Patients undergoing anterior segment surgery at Nanfang Hospital, Southern Medical University, will be included in this study. SS-OCT will be used to assess ocular anatomical parameters, and the collected measurements will be analyzed to characterize anatomical features and explore potential differences among patients undergoing different types of anterior segment surgery.

The findings of this study may improve understanding of ocular anatomical characteristics in patients undergoing anterior segment surgery and provide useful information for clinical assessment and surgical management.

Eligibility

Sex
ALL
Min age
18 Years
Max age
90 Years
Healthy volunteers
No
Inclusion Criteria: * Voluntary provision of written informed consent. * 18≤Age≤90 years. * Patients diagnosed by an ophthalmologist with cataract, primary angle-closure disease, or other anterior segment disorders requiring anterior segment surgery. * Availability of complete or accessible preoperative and postoperative clinical records and ophthalmic examination data. Exclusion Criteria: * Follow-up duration of less than 3 months. * Substantial missing ophthalmic examination or perioperative data that prevents the required study analyses. * Inability to obtain valid anterior segment imaging data due to severe corneal opacity, poor ocular fixation, inadequate cooperation, or other related factors. * Presence of severe ocular trauma, intraocular tumors, severe corneal disease, active intraocular inflammation, or other ocular conditions that may substantially affect anterior segment structural assessment. * History of complex intraocular surgery that may significantly alter anterior segment anatomy and is considered unsuitable for inclusion by the investigator. * Other conditions considered by the investigator to make the patient unsuitable for participation in the study.

Primary outcome measure(s)

  • Change in Anterior Chamber Depth (ACD) — Preoperative baseline; postoperative day 1, week 1, month 1, and month 3
    Anterior chamber depth (ACD), defined as the distance from the posterior corneal surface to the anterior lens surface along the visual axis, will be measured in millimeters (mm) using swept-source anterior segment optical coherence tomography (SS-OCT; CASIA2). Changes from the preoperative baseline will be calculated at each postoperative follow-up visit.
  • Change in Anterior Chamber Width (ACW) — Preoperative baseline; postoperative day 1, week 1, month 1, and month 3
    Anterior chamber width (ACW), defined as the distance between the nasal and temporal scleral spurs, will be measured in millimeters (mm) using swept-source anterior segment optical coherence tomography (SS-OCT; CASIA2). Changes from the preoperative baseline will be calculated at each postoperative follow-up visit.
  • Change in Anterior Chamber Volume (ACV) — Preoperative baseline; postoperative day 1, week 1, month 1, and month 3
    Anterior chamber volume (ACV) will be quantified in cubic millimeters (mm³) using the anterior chamber analysis function of swept-source anterior segment optical coherence tomography (SS-OCT; CASIA2). Changes from the preoperative baseline will be calculated at each postoperative follow-up visit.
  • Change in Angle Opening Distance at 500 μm (AOD500) — Preoperative baseline; postoperative day 1, week 1, month 1, and month 3
    Angle opening distance at 500 μm (AOD500) will be measured in millimeters (mm) using swept-source anterior segment optical coherence tomography (SS-OCT; CASIA2). AOD500 is defined as the distance between the corneal endothelium and the anterior iris surface along a line perpendicular to the trabecular meshwork at 500 μm from the scleral spur. Changes from the preoperative baseline will be calculated at each postoperative follow-up visit.
  • Change in Trabecular-Iris Space Area at 500 μm (TISA500) — Preoperative baseline; postoperative day 1, week 1, month 1, and month 3
    Trabecular-iris space area at 500 μm (TISA500) will be measured in square millimeters (mm²) using swept-source anterior segment optical coherence tomography (SS-OCT; CASIA2). TISA500 represents the cross-sectional area of the anterior chamber angle bounded by the trabecular meshwork, anterior iris surface, and reference lines at the scleral spur and 500 μm from the scleral spur. Changes from the preoperative baseline will be calculated at each postoperative follow-up visit.
  • Change in Trabecular-Iris Angle at 500 μm (TIA500) — Preoperative baseline; postoperative day 1, week 1, month 1, and month 3
    Trabecular-iris angle at 500 μm (TIA500) will be measured in degrees using swept-source anterior segment optical coherence tomography (SS-OCT; CASIA2). The angle will be determined from the anterior chamber angle geometry at 500 μm from the scleral spur. Changes from the preoperative baseline will be calculated at each postoperative follow-up visit.
  • Change in Iris Curvature (IC) — Preoperative baseline; postoperative day 1, week 1, month 1, and month 3
    Iris curvature (IC) will be quantified in millimeters (mm) using swept-source anterior segment optical coherence tomography (SS-OCT; CASIA2). Iris curvature is defined as the maximum perpendicular distance between the posterior iris surface and a reference line connecting the iris root to the pupillary margin. Changes from the preoperative baseline will be calculated at each postoperative follow-up visit.

Trial sites (1)

FacilityCityRegionStatus
Nanfang Hospital, Southern Medical University Guangzhou Guangdong Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07903454 on ClinicalTrials.gov ↗ ← All trials in China