No Additional Experimental Intervention: No Additional Experimental Intervention
Study summary
Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and the control group, there are differentially expressed molecules in PACG patients with zonular laxity, and a potential mechanistic network can be constructed therefrom.
Eligibility
Sex
ALL
Min age
50 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* Clinically diagnosed with primary angle-closure glaucoma (PACG)
* Aged ≥ 50 years, no gender restriction
* Case Group A: Undergoing glaucoma surgery with intraoperatively confirmed significant zonular laxity
* Case Group B: Undergoing glaucoma surgery with intraoperatively confirmed normal zonular morphology
* Control group: age- and sex-matched with case groups; clinically diagnosed with age-related cataract; normal anterior chamber depth and angle; no history or signs of glaucoma; undergoing cataract surgery
Exclusion Criteria:
* Secondary glaucoma
* History of previous intraocular surgery
* Systemic diseases that can cause abnormal ocular zonules
* Other severe ocular diseases
* Long-term use of medications affecting connective tissue metabolism
Primary outcome measure(s)
Concentration of differentially expressed molecules in PACG patients with zonular laxity — 2 years Compared with primary angle-closure glaucoma (PACG) patients without zonular laxity and healthy control subjects, differentially expressed molecules will be identified and quantified by high-throughput omics sequencing and bioinformatics analysis in PACG patients with zonular laxity, and a potential mechanistic network will be constructed based on these molecular changes.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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