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Clinical Trials in China / NCT07886892
Starting soon Not applicable

Computed Inspiratory Muscle Pressure to Monitor Inspiratory Effort During Pressure Support Ventilation

NCT07886892 · tracked via the Priya Life Science China tracker
Sponsor
Jian-Xin Zhou
Phase
Not applicable
Started
2026-11-01
Last updated
2026-10-21

Condition(s) studied

Mechanical VentilationCritical Care

Investigational drug(s) / intervention(s)

Pressure support 15Pressure support 13Pressure support 11Pressure support 9Pressure support 7Pressure support 5

Pressure support 15: Pressure support of 15 cm H2O will be applied for 10 minutes.

Pressure support 13: Pressure support of 13 cm H2O will be applied for 10 minutes.

Pressure support 11: Pressure support of 11 cm H2O will be applied for 10 minutes.

Pressure support 9: Pressure support of 9 cm H2O will be applied for 10 minutes.

Pressure support 7: Pressure support of 7 cm H2O will be applied for 10 minutes.

Pressure support 5: Pressure support of 5 cm H2O will be applied for 10 minutes.

Study summary

The goal of this study is to validate computed inspiratory muscle pressure (cPmus) for monitoring inspiratory effort in adults receiving pressure support ventilation. Researchers will compare cPmus with reference inspiratory muscle pressure calculated using an esophageal balloon catheter, a thin pressure-measuring tube placed in the esophagus. The study will look at how closely the two methods are related and whether they give similar results. Participants will undergo simultaneous monitoring with cPmus and an esophageal balloon catheter. Researchers will adjust pressure support across six levels, recording measurements from both methods at each level.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: 1. Age 18 years or older. 2. Receiving pressure support ventilation. 3. Written informed consent provided by the participant or a legally authorized representative. Exclusion Criteria: 1. Contraindication to esophageal catheter placement, including uncontrolled coagulopathy, skull base fracture, upper gastrointestinal bleeding, tumor or surgery, neck surgery, or esophagogastric varices. 2. Chest trauma, a postoperative state following lung surgery, an active pulmonary air leak (pneumothorax, pneumomediastinum, or bronchopleural fistula), or an indwelling chest drain. 3. Neuromuscular disease, diaphragmatic dysfunction, or diaphragmatic surgery. 4. Impaired central respiratory drive due to intracranial hypertension or brainstem injury. 5. Hemodynamic instability, defined as mean arterial pressure \<60 mmHg, systolic blood pressure \>180 mmHg, heart rate \<40 or \>150 beats/min, or norepinephrine dose \>1 mcg/kg/min. 6. Pregnancy or breastfeeding. 7. A decision to withdraw life-sustaining treatment or provide palliative care.

Primary outcome measure(s)

  • Computed inspiratory muscle pressure (cPmus) — 2 hours
    Computed inspiratory muscle pressure (cPmus) will be measured.
  • Inspiratory muscle pressure (Pmus) — 2 hours
    Inspiratory muscle pressure (Pmus) will be measured.
  • Computed inspiratory muscle pressure-time product (cPTPmus) — 2 hours
    Computed inspiratory muscle pressure-time product (cPTPmus) will be measured.
  • Inspiratory muscle pressure-time product (PTPmus) — 2 hours
    Inspiratory muscle pressure-time product (PTPmus) will be measured.

Trial sites (1)

FacilityCityRegionStatus
Beijing Shijitan Hospital Beijing China

More Jian-Xin Zhou trials in China

Use of Nasal Pressure to Assess Inspiratory Effort Under Different Oxygen Treatments Recruiting
Computed Inspiratory Muscle Pressure to Monitor Inspiratory Effort During Pressure-Targeted Assist/Control Ventilation Starting soon
Pulmonary Microbiota Changes and Clinical Outcomes in Neurosurgical ICU Patients With Artificial Airways Recruiting
Comparison of Physiological Effects of Two Types of High-Flow Oxygen Therapy in Tracheostomized Patients Starting soon
Comparison of Physiological Effects of Two High-Flow Tracheal Oxygen Versus T-Piece During Spontaneous Breathing Trials Recruiting

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Use of Nasal Pressure to Assess Inspiratory Effort Under Different Oxygen Treatments Recruiting
Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability Recruiting
Pulse Wave vs. Saline Contrast EIT for Pulmonary Perfusion in ARDS Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07886892 on ClinicalTrials.gov ↗ ← All trials in China