Modified high flow tracheal oxygenStandard high flow tracheal oxygen
Modified high flow tracheal oxygen: Modified high-flow tracheal oxygen with flow rates of 40L/min and 60L/min will be performed.
Standard high flow tracheal oxygen: Standard high-flow tracheal oxygen with flow rates of 40 L/min and 60 L/min will be performed.
Study summary
High-flow nasal oxygen therapy offers benefits like precise oxygen delivery, flow-related positive end-expiratory pressure generation and improved lung function. High-flow oxygen therapy can be applied via tracheostomy as high-flow tracheal oxygen. While high-flow tracheal oxygen has been used to facilitate weaning, it has diminished physiological effects due to bypassing upper airways. To enhance its effectiveness, researchers developed a modified high-flow tracheal oxygen tube with a smaller expiratory end diameter to increase airway resistance and pressure. This is a prospective randomized crossover study that aims to compare the physiological effects of standard and modified high-flow oxygen therapy in tracheostomized patients.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
Tracheostomy with stable spontaneous breathing.
Exclusion Criteria:
1. Age younger than 18 years old
2. Pregnancy
3. Hemodynamic instability (mean arterial pressure \<60 mmHg, heart rate \>140 or \<60 bpm)
4. Respiratory and oxygenation instability (respiratory rate \> 35bpm or oxygen saturation measured by pulse oximetry \<90%)
5. Neuromuscular diseases or phrenic nerve injury
6. Recent trauma or surgery to the trachea, esophagus, neck, chest, or stomach
7. Pneumothorax or placement of a chest drainage
8. Contraindication to electrical impedance tomography (EIT) (implantable defibrillator)
9. Anticipating withdrawal of life support
Primary outcome measure(s)
Mean expiratory airway pressure — From enrollment to the end of treatment at 4 hours Mean expiratory airway pressure will be measured during standard and modified high-flow tracheal oxygen.
Positive end-expiratory pressure — From enrollment to the end of treatment at 4 hours Positive end-expiratory pressure will be measured during standard and modified high-flow tracheal oxygen.
Change of end-expiatory lung volume — From enrollment to the end of treatment at 4 hours Change of end-expiatory lung volume will be measured during standard and modified high-flow tracheal oxygen.
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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