Clinical Trials in China / NCT07846059
Starting soon
Observational
Evaluation of Mavacamten-Based Practice in Chinese Adults With Obstructive Hypertrophic Cardiomyopathy
NCT07846059 · tracked via the Priya Life Science China tracker
Condition(s) studied
Obstructive Hypertrophic Cardiomyopathy (oHCM)
Study summary
The study will describe how mavacamten is used in routine care for Chinese adults with symptomatic obstructive hypertrophic cardiomyopathy (oHCM), including use as monotherapy or with other background/concomitant oHCM medications.
Eligibility
Inclusion Criteria:
Participants must meet all of the following criteria to be included:
1. Diagnosis: Have a documented diagnosis of obstructive hypertrophic cardiomyopathy (oHCM), identified by the corresponding International Classification of Diseases (ICD)-10 codes in the medical record system.
2. Medication Exposure: Have a first-ever recorded prescription for Mavacamten within the Patient Identification Period (24 October 2024 to 31 March 2026). This date is defined as the Index Date.
3. Age: Be ≥ 18 years of age at the Index Date.
4. Treatment Continuity: Have at least two valid clinical records of any type (e.g., outpatient visit, inpatient encounter, prescription refill, laboratory test, or echocardiogram) after the Index Date.
Exclusion Criteria:
Participants meeting any of the following criteria will be excluded:
(1) Prior Use of Study Drug: Have any documented history of Mavacamten use (based on medical history records, prescription records, or clinical notes) at any time prior to the Index Date.
Primary outcome measure(s)
- Number of participants in each study cohort — Baseline and months 1, 2, 3, 6, 9, 12 and 15
- Absolute change (mmHg) from baseline in resting peak left ventricular outflow tract (LVOT) gradient assessed by transthoracic echocardiography — Baseline and at months 1, 2, 3, 6, 9, 12 and 15
- Absolute change (mmHg) from baseline in post-Valsalva peak left ventricular outflow tract (LVOT) gradient assessed by transthoracic echocardiography — Baseline and at months 1, 2, 3, 6, 9, 12 and 15
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| Fudan University Zhongshan Hospital | Shanghai | China |
More Bristol-Myers Squibb trials in China
Other trials for the same condition
Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07846059 on ClinicalTrials.gov ↗ ← All trials in China