Multi-Center Study of Natural History in Atypical Parkinsonian Syndromes (MAPS-NH)

NCT07805967 · tracked via the Priya Life Science China tracker

Sponsor

Second Affiliated Hospital of Soochow University

Phase

Observational

Started

2025-11-12

Last updated

2026-09-08

Condition(s) studied

Multiple System AtrophyDementia With Lewy Bodies (DLB)Progressive Supranuclear Palsy (PSP)Corticobasal Degeneration (CBD)

Investigational drug(s) / intervention(s)

We did not apply any interventions; only observational research was conducted.

We did not apply any interventions; only observational research was conducted.: We did not apply any interventions; only observational research was conducted.

Study summary

This goal of this observational study is to clarify the variations in the natural course of atypical parkinsonian syndromes (APS, including MSA, DLB, PSP, and CBD), such as the progression rate of motor and non-motor symptoms and characteristic imaging evolution patterns. Establish a comprehensive assessment framework for APS, and develop clinical and biological databases to identify biomarkers with early predictive value.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: 1. MSA : Meets the "probable MSA" criteria in the 2022 Chinese expert consensus on MSA diagnosis (MSA-P or MSA-C subtype); disease duration ≤3 years (from onset of first motor symptoms) . 2. DLB : Meets "probable DLB" criteria per the 2017 McKeith diagnostic criteria; MMSE ≥18 (to exclude severe dementia confounding assessment) . 3. PSP : Meets "probable PSP-Richardson syndrome" criteria per the 2017 PSP diagnostic standards; vertical gaze palsy or postural instability with duration ≤2 years . 4. CBD : Meets "probable CBD" criteria per the 2019 Chinese expert consensus on corticobasal degeneration diagnosis and treatment; asymmetric cortical symptoms (apraxia/dystonia/alien limb). Exclusion Criteria: 1. Parkinson's disease , spinocerebellar ataxia (SCA) and other secondary autonomic failure . 2. Vascular parkinsonism , Parkinsonism caused by stroke , tumor , or immune-mediated encephalitis .

Primary outcome measure(s)

Natural disease progression of various atypical parkinsonian syndromes — up to 36 months
To observe the differences in the natural disease progression of various atypical parkinsonian syndromes (APS, including MSA, DLB, PSP, and CBD), such as the progression rates of motor and non-motor symptoms and the patterns of imaging evolution. The preliminary study design involves a follow-up period of 3 years, with assessments of clinical phenotypes and/or biomarker changes every 6 months.

Trial sites (20)

Facility	City	Region	Status
Changshu Hospital Affiliated to Nanjing University of Chinese Medicine	Changshu	Jiangsu	Recruiting
The second People's Hospital of Huai'an	Huai'an	Jiangsu	Not Yet Recruiting
The First People's Hospial of Kunshan	Kunshan	Jiangsu	Not Yet Recruiting
Jiangsu Province Official Hospital	Nanjing	Jiangsu	Not Yet Recruiting
The Second Affiliated Hospital of Nantong University	Nantong	Jiangsu	Not Yet Recruiting
Jiangsu Province (Suqian) Hospital	Suqian	Jiangsu	Recruiting
The Forth Affiliated Hospital of Soochow University	Suzhou	Jiangsu	Recruiting
The Second Affiliated Hospital of Soochow University	Suzhou	Jiangsu	Recruiting
The Second Affiliated Hospital of Xuzhou Medical University	Xuzhou	Jiangsu	Not Yet Recruiting
Yancheng Third People's Hospital	Yancheng	Jiangsu	Recruiting
Affiliated Hospital of Yangzhou University	Yangzhou	Jiangsu	Not Yet Recruiting
Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine/Zhangjiagang Traditional Chinese Medicine Hospital	Zhangjiagang	Jiangsu	Not Yet Recruiting
The Forth People's Hospital of Zhenjiang	Zhenjiang	Jiangsu	Recruiting
Yantai Yuhuangding Hospital	Yantai	Shandong	Not Yet Recruiting
Mianyang 404 Hospital	Mianyang	Sichuan	Not Yet Recruiting
Jiaxing Second Hospital	Jiaxing	Zhejiang	Not Yet Recruiting
Deyang People's Hospital	Deyang	China	Not Yet Recruiting
Changxing people' s hospital	Huzhou	China	Not Yet Recruiting
Affiliated Hospital of Nantong University	Nantong	China	Not Yet Recruiting
The Affiliated Hospital of Xuzhou Medical University	Xuzhou	China	Not Yet Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07805967 on ClinicalTrials.gov ↗ ← All trials in China