Propofol vs. Ciprofol for Anesthesia Induction in Frail Elderly Patients

NCT07663695 · tracked via the Priya Life Science China tracker

Sponsor

General Hospital of Ningxia Medical University

Phase

Not applicable

Started

2026-06-25

Last updated

2026-06-23

Condition(s) studied

Hypotension

Investigational drug(s) / intervention(s)

Ciprofol →Propofol →

Ciprofol: An innovative 2,6-disubstituted phenol derivative used for general anesthesia induction.

Propofol: An alkylphenol derivative and standard intravenous anesthetic agent used for general anesthesia induction.

Study summary

Post-induction hypotension (PIH) is a common and critical complication during general anesthesia, particularly in frail elderly patients whose physiological reserves are significantly diminished. PIH is strongly associated with adverse postoperative outcomes, including acute kidney injury (AKI) and myocardial injury. Propofol is the most widely used induction agent but frequently induces circulatory depression. Ciprofol, a novel anesthetic agent developed by optimizing the molecular structure of propofol, has demonstrated improved hemodynamic stability and fewer adverse effects in general populations. However, its specific impact on frail elderly patients remains unestablished.

The primary purpose of this single-center, randomized, double-blind, controlled trial is to compare the effects of propofol and ciprofol during anesthesia induction on the incidence of PIH in frail elderly patients undergoing major abdominal surgery. The investigator's hypothesis is that ciprofol will significantly lower the incidence of PIH compared to propofol. Additionally, the study will evaluate secondary clinical outcomes, such as postoperative AKI, postoperative cardiac complications, and the overall quality of recovery, to provide an evidence-based clinical guide for selecting optimal induction agents for this vulnerable patient population.

Eligibility

Sex

ALL

Min age

60 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Patients scheduled to undergo major abdominal surgery under general anesthesia. * Frailty score \>= 3\[cite: 2\]. * Age \>= 60 years\[cite: 2\]. * American Society of Anesthesiologists (ASA) physical status class \>= II\[cite: 2\]. * Planned invasive blood pressure monitoring\[cite: 2\]. Exclusion Criteria: * Severe cardiac arrhythmia\[cite: 2\]. * Severe valvular heart disease\[cite: 2\]. * Poorly controlled hypertension with medication (systolic blood pressure \>= 180 mmHg and/or diastolic blood pressure \>= 110 mmHg)\[cite: 2\]. * Pre-existing preoperative hypotension (mean arterial pressure \< 65 mmHg)\[cite: 2\]. * Preoperative renal dysfunction (serum creatinine greater than the upper limit of normal)\[cite: 2\].

Primary outcome measure(s)

Incidence of post-induction hypotension (PIH) — From the initiation of general anesthesia drug administration until 10 minutes after endotracheal intubation.
Post-induction hypotension (PIH) is defined as a mean arterial pressure (MAP) \< 65 mmHg lasting for more than 1 minute.

Trial sites (1)

Facility	City	Region	Status
General Hospital of Ningxia Medical University	Yinchuan	Ningxia

More General Hospital of Ningxia Medical University trials in China

Effect of Preoxygenation Position and Examination Position on Hypoxemia During Painless Gastrointestinal Endoscopy Starting soon

Perioperative EEG Prediction of Postoperative Sleep Disturbance in Gynecologic Laparoscopic Surgery Enrolling by invitation

Wearable Device-Based Analysis of the Relationship Between Sleep Patterns and Clinical Prognosis in Patients With Traumatic Brain Injury Recruiting

Effects of Preoperative Sleep Disorders on Perioperative Anesthesia Depth and Recovery Quality in Patients Undergoing Noncardiac Surgery Recruiting

External Oblique Intercostal Block Versus Transversus Abdominis Plane Combined With Rectus Sheath Block on Postoperative Pain in Laparoscopic Radical Gastrectomy Recruiting

Other trials for the same condition

PeRsonalized Blood prEssure Management on Postoperative Complications and Mortality in hIgh-risk Patients Undergoing Major Non-cardiac Surgery Recruiting

Efficacy and Safety Evaluation of Non-invasive Temporal Interference Stimulation for Blood Pressure Regulation Starting soon

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07663695 on ClinicalTrials.gov ↗ ← All trials in China