The Effect of Esketamine on Cough Reflex During Tracheal Extubation in Patients Undergoing Open Thyroid Surgery

Condition(s) studied

Investigational drug(s) / intervention(s)

Esketamine: After anesthesia induction, continue to administer esketamine by infusion at 0.1 mg/kg/h during the maintenance phase of anesthesia, and stop the infusion of esketamine during suturing.

Normal Saline: After anesthetic induction, an equal amount of saline is continuously infused by pump during the maintenance phase of anesthesia, and the saline infusion is stopped during suturing;

Study summary

This study intends to conduct a prospective randomized controlled trial to implement esketamine-assisted anesthesia in patients undergoing open thyroidectomy, in order to observe the effect of esketamine on coughing during extubation in thyroidectomy patients.

Eligibility

Primary outcome measure(s)

• Incidence of coughing during tracheal extubation — perioperative (From the awakening period to immediately after tracheal extubation)
  2 point scales; 0=None; 0 = Did not occur; 1 = Occurred;

Trial sites (1)

More The Second Hospital of Anhui Medical University trials in China

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