Esketamine: After anesthesia induction, continue to administer esketamine by infusion at 0.1 mg/kg/h during the maintenance phase of anesthesia, and stop the infusion of esketamine during suturing.
Normal Saline: After anesthetic induction, an equal amount of saline is continuously infused by pump during the maintenance phase of anesthesia, and the saline infusion is stopped during suturing;
Study summary
This study intends to conduct a prospective randomized controlled trial to implement esketamine-assisted anesthesia in patients undergoing open thyroidectomy, in order to observe the effect of esketamine on coughing during extubation in thyroidectomy patients.
Eligibility
Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
No
Inclusion Criteria:
* Patients scheduled for elective open thyroid surgery
* ASA class I-II
* Voluntarily participate in the study and sign the informed consent form
Exclusion Criteria:
* Body Mass Index \> 30 kg/m²
* Patients with unstable ischemic cardiomyopathy, pulmonary hypertension, poorly controlled or untreated hypertension (arterial hypertension, resting systolic/diastolic blood pressure \>180/100 mmHg)
* Hepatic or renal dysfunction
* History of oral, maxillofacial, neck, or airway surgery, or pathological structural alterations
* Respiratory diseases (COPD, asthma, inflammation, chronic cough)
* Patients with elevated intracranial pressure
* Patients undergoing repeat surgery
* History of allergy to the investigational drug used in the study
* Patients with psychiatric disorders or alcohol abuse (daily ethanol intake ≥40 g, or having experienced alcohol withdrawal within the past 6 months, or unable to control alcohol consumption)
Primary outcome measure(s)
Incidence of coughing during tracheal extubation — perioperative (From the awakening period to immediately after tracheal extubation) 2 point scales; 0=None; 0 = Did not occur; 1 = Occurred;
Trial sites (1)
Facility
City
Region
Status
Second Affiliated Hospital of Anhui Medical University
Hefei
Anhui
More The Second Hospital of Anhui Medical University trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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