Immediate Electrophysiological Effects of Different Atrial Pacing Sites on P-Wave Characteristics

NCT07603648 · tracked via the Priya Life Science China tracker

Sponsor

Shanghai Tong Ren Hospital

Phase

Not applicable

Started

2026-03-31

Last updated

2026-05-22

Condition(s) studied

Pacing TherapyCardiac Pacing

Investigational drug(s) / intervention(s)

Multi-site short-time pacing

Multi-site short-time pacing: Short-time atrial pacing at right atrial appendage (RAA), atrial septum, Bachmann's bundle (BB) area, and posterosuperior bundle (PSB) regions (high and low levels) during regular pacemaker implantation procedures are applied for acute electrocardiogram and echocardiogram testings.

Study summary

This is a prospective, single-center, non-randomized, within-subject interventional study. The purpose is to compare the immediate effects of different atrial pacing sites on atrial electrical activation, as reflected by P-wave characteristics on surface electrocardiography (ECG).

During pacemaker implantation, short-term pacing will be performed sequentially at multiple predefined atrial sites, including the right atrial appendage (RAA), atrial septum, Bachmann's bundle (BB) area, and posterosuperior bundle (PSB) regions. ECG parameters will be recorded at each site to evaluate differences in P-wave duration and morphology.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Age ≥18 years * Sinus rhythm at baseline * Indication for permanent pacemaker implantation with planned atrial lead placement * Willing and able to provide written informed consent Exclusion Criteria: * Long-standing persistent or permanent atrial fibrillation, or prior atrioventricular node ablation * Prior cardiac implantable electronic device (CIED) requiring revision, replacement, or upgrade * Indication for implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT-D) * Significant valvular heart disease, cardiomyopathy, or prior cardiac surgery * Angina or acute myocardial infarction within 3 months before enrollment * Chronic use of antiarrhythmic drugs * Severe hepatic or renal dysfunction, or other serious systemic diseases * Participation in another clinical study that may interfere with the objectives of this study

Primary outcome measure(s)

Atrial-paced ECG P-wave duration — During implantation

Trial sites (2)

Facility	City	Region	Status
Affiliated Hospital of Zunyi Medical College	Zunyi	Guizhou	Not Yet Recruiting
Tong Ren Hospital, Shanghai Jiaotong University School of Medicine	Shanghai	Shanghai Municipality	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07603648 on ClinicalTrials.gov ↗ ← All trials in China