Posterosuperior Bundle Pacing for Prevention of Atrial Fibrillation in Patients With Sinus Node Dysfunction
Condition(s) studied
Investigational drug(s) / intervention(s)
RAA pacing: Atrial pacing lead implanted at the right atrial appendage. Left bundle branch area pacing will be applied if ventricular pacing is necessary.
PSB pacing: Atrial pacing lead implanted at the posterosuperior bundle region. Left bundle branch area pacing will be applied if ventricular pacing is necessary.
Study summary
This study aims to evaluate whether posterosuperior bundle (PSB) pacing reduces the incidence of atrial fibrillation (AF) in patients with sinus node dysfunction (SND) undergoing pacemaker implantation. Approximately 300 patients will be enrolled and randomized to receive atrial pacing at either the PSB region or the right atrial appendage (RAA). The primary endpoint is the occurrence of AF episodes lasting ≥6 minutes, as detected by device or surface electrocardiogram. Patients will be followed for up to 24 months.
Eligibility
Primary outcome measure(s)
- Incidence of atrial fibrillation — From implantation to regular follow-ups up to 24 months
Incidence of atrial fibrillation ≥ 6 minutes during follow-ups
Trial sites (10)
| Facility | City | Region | Status |
|---|---|---|---|
| China Medical University affiliated AnQing Municipal Hospital | Anqing | Anhui | Not Yet Recruiting |
| Tongling People's Hospital | Tongling | Anhui | Not Yet Recruiting |
| Affiliated Hospital of Zunyi Medical College | Zunyi | Guizhou | Not Yet Recruiting |
| Wuhan Asia General Hospital | Wuhan | Hubei | Not Yet Recruiting |
| Tong Ren Hospital, Shanghai Jiaotong University School of Medicine | Shanghai | Shanghai Municipality | Recruiting |
| Fudan University affiliated Huadong Hospital | Shanghai | Shanghai Municipality | Not Yet Recruiting |
| Shanghai Jiaotong University affiliated Shanghai Ninth People's Hospital | Shanghai | Shanghai Municipality | Not Yet Recruiting |
| Shanghai Jiaotong University affiliated Shanghai Sixth People's Hospital | Shanghai | Shanghai Municipality | Not Yet Recruiting |
| Shanghai University of Traditional Chinese Medicine affiliated Putuo Hospital | Shanghai | Shanghai Municipality | Not Yet Recruiting |
| Tongji University School of Medicine affiliated Tongji University | Shanghai | Shanghai Municipality | Not Yet Recruiting |
More Shanghai Tong Ren Hospital trials in China
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07645066 on ClinicalTrials.gov ↗ ← All trials in China