China-NINE Cohort：Neuroimmune Network in Elderly / Neurodegeneration

Condition(s) studied

Study summary

This is an observational study aimed at understanding the cognitive, functional, and behavioral characteristics of Chinese patients with cognitive impairment, exploring the underlying mechanisms, and providing evidence for early diagnosis, treatment, and care of cognitive disorders including dementia.

Eligible participants will undergo a series of assessments and examinations, including cognitive and memory scale tests, routine blood tests, ApoE genetic testing, cerebrospinal fluid testing, brain MRI, functional MRI, and FDG-PET/AV45-PET scans when necessary. Additional samples such as saliva, nasal secretions, and stool may also be collected. Most evaluations are provided free of charge to support diagnosis and treatment guidance.

Participation is voluntary. All personal information and research data will be kept confidential. Potential benefits include access to expert clinical care and free cognitive assessments for disease evaluation. Possible inconveniences include time commitment and temporary discomfort during examinations; medical support will be provided if needed.

Eligibility

Primary outcome measure(s)

• Degree and Type of Cognitive Impairment Assessed by Neuropsychological Scales — From enrollment to the end of treatment at 3 years
  Higher scores indicate better cognitive function; lower scores indicate more severe cognitive impairment.

Trial sites (2)

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