Establishment of a Sleep and Sleep-disorder Research Cohort in Patients With Neurological Disorders

Condition(s) studied

Investigational drug(s) / intervention(s)

Symptomatic and Etiological Treatment: sleep-related

Study summary

This study aims to establish a research cohort on sleep and sleep disorders in patients with neurological diseases to systematically evaluate the relationship between various neurological conditions and sleep characteristics or disturbances.

Eligibility

Primary outcome measure(s)

• Total sleep time measured by polysomnography — baseline, 3 months and one year
  Total sleep time is defined as the total amount of time spent asleep during the overnight polysomnography recording, expressed in minutes.
• Wake after sleep onset measured by polysomnography — baseline, 3 months and one year
  Wake after sleep onset is defined as the total duration of wakefulness after sleep onset and before final awakening during the overnight polysomnography recording, expressed in minutes.
• Sleep onset latency measured by polysomnography — baseline, 3 months and one year
  Sleep onset latency is defined as the time from lights off to the first epoch of sleep during overnight polysomnography.
• Number of arousal events measured by polysomnography — baseline, 3 months and one year
  The number of arousal events is defined as the total number of arousals occurring during the overnight polysomnography recording.
• Rapid eye movement sleep onset latency measured by polysomnography — baseline, 3 months and one year
  Rapid eye movement sleep onset latency is defined as the interval between sleep onset and the first occurrence of rapid eye movement sleep during the overnight polysomnography recording, expressed in minutes.
• Non rapid eye movement sleep stage 1, 2, 3, and rapid eye movement sleep time measured by polysomnography — baseline, 3 months and one year
  Non-rapid eye movement (NREM) sleep stages 1, 2, and 3, and rapid eye movement (REM) sleep time are defined as the total duration spent in each sleep stage during overnight polysomnography, expressed in minutes.
• Number of awakenings related to the event measured by polysomnography — baseline, 3 months and one year
  The number of awakenings related to respiratory events is defined as the total count of awakenings temporally associated with respiratory events during overnight polysomnography.
• Number of respiratory events measured by polysomnography — baseline, 3 months and one year
  The number of respiratory events is defined as the total count of apnea and hypopnea events identified during overnight polysomnography.
• Number of decreases in oxygen saturation measured by polysomnography — baseline, 3 months and one year
  The number of respiratory events is defined as the total count of respiratory events identified during overnight polysomnography.
• Sleep period heart rate measured by polysomnography — baseline, 3 months and one year
  Sleep period heart rate is defined as the average heart rate measured during the sleep period as recorded by overnight polysomnography.
• Number of rapid eye movement sleep without atonia measured by polysomnography — baseline, 3 months and one year
  The number of rapid eye movement sleep without atonia events is defined as the total count of rapid eye movement sleep epochs exhibiting increased muscle activity during overnight polysomnography.
• Hypoxic burden measured by polysomnography — baseline, 3 months and one year
  Hypoxic burden is a quantitative measure of the cumulative severity of nocturnal hypoxemia, calculated from overnight polysomnography. It represents the total area under the curve of oxygen desaturation events, integrating both the depth and duration of oxygen desaturation across the entire sleep period.

Trial sites (1)

More The First Hospital of Jilin University trials in China

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