The purpose of this study is to access the clinical characteristics and risk factors for neurological sequelae after acute carbon monoxide poisoning.
Eligibility
Sex
ALL
Min age
16 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* patients present within 12 hours after acute carbon monoxide poisoning;
* age older than 16 years.
Exclusion Criteria:
* pregnant women；
* patients receive oxygen therapy before presentation;
* have history of acute carbon monoxide poisoning within 1 year;
* have been diagnosed any of the following disease: Parkinson disease; cognitive disorder, psychiatric disorders, sequelae of cerebral infarction or hemorrhage, chronic kidney disease and receive hemodialysis, congestive heart failure ( NYHA class III-IV)
Primary outcome measure(s)
Changes of Mini-mental State Examination (MMSE) score at 6 weeks — Changes of score from baseline to 6 weeks Score ranges from 0 to 30, a lower score means a worse outcome.
Changes of Mini-mental State Examination (MMSE) score at 6 months — Changes of score from baseline to 6 months Score ranges from 0 to 30, a lower score means a worse outcome.
Changes of Mini-mental State Examination (MMSE) score at 12 months — Changes of score from baseline to 12 months Score ranges from 0 to 30, a lower score means a worse outcome.
Changes of Montreal cognitive assessment (MoCA）score at 6 weeks — Changes of score from baseline to 6 weeks Score ranges from 0 to 30, a lower score means a worse outcome.
Changes of Montreal cognitive assessment (MoCA）score at 6 months — Changes of score from baseline to 6 months Score ranges from 0 to 30, a lower score means a worse outcome.
Changes of Montreal cognitive assessment (MoCA）score at 12 months — Changes of score from baseline to 12 months Score ranges from 0 to 30, a lower score means a worse outcome.
Changes of Hamilton Depression Scale(HAMD) score at 6 weeks — Changes of score from baseline to 6 weeks Score ranges from 0 to 54, a higher score means a worse outcome.
Changes of Hamilton Depression Scale(HAMD) score at 6 months — Changes of score from baseline to 6 months Score ranges from 0 to 54, a higher score means a worse outcome.
Changes of Hamilton Depression Scale(HAMD) score at 12 months — Changes of score from baseline to 12 months Score ranges from 0 to 54, a higher score means a worse outcome.
Changes of Hamilton Anxiety Scale (HAMA) score at 6 weeks — Changes of score from baseline to 6 weeks Score ranges from 0 to 56, a higher score means a worse outcome.
Changes of Hamilton Anxiety Scale (HAMA) score at 6 months — Changes of score from baseline to 6 months Score ranges from 0 to 56, a higher score means a worse outcome.
Changes of Hamilton Anxiety Scale (HAMA) score at 12 months — Changes of score from baseline to 12 months Score ranges from 0 to 56, a higher score means a worse outcome.
Changes of Activity of Daily Living (ADL) score at 6 weeks — Changes of score from baseline to 6 weeks Score ranges from 0 to 80, a higher score means a worse outcome.
Changes of Activity of Daily Living (ADL) score at 6 months — Changes of score from baseline to 6 months Score ranges from 0 to 80, a higher score means a worse outcome.
Changes of Activity of Daily Living (ADL) score at 12 months — Changes of score from baseline to 12 months Score ranges from 0 to 80, a higher score means a worse outcome.
Changes of self-evaluation of discomfort symptoms scale at 1 week — Changes of score from baseline to 1 week This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome
Changes of self-evaluation of discomfort symptoms scale at 3 weeks — Changes of score from baseline to 3 weeks This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome
Changes of self-evaluation of discomfort symptoms scale at 6 weeks — Changes of score from baseline to 6 weeks This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome
Changes of self-evaluation of discomfort symptoms scale at 6 months — Changes of score from baseline to 6 months This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome
Changes of self-evaluation of discomfort symptoms scale at 12 months — Changes of score from baseline to 12 months This is a self designed questionnaire, score ranges from 0 to 66, a higher score means a worse outcome
Trial sites (1)
Facility
City
Region
Status
First Hospital of Jilin University
Changchun
Jilin
More The First Hospital of Jilin University trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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