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Clinical Trials in China / NCT07334067
Starting soon Not applicable

Site Preservation Was Performed Through an Open Healing Oral Restorative Membrane

NCT07334067 · tracked via the Priya Life Science China tracker
Sponsor
The Dental Hospital of Zhejiang University School of Medicine
Phase
Not applicable
Started
2025-12-15
Last updated
2026-01-12

Condition(s) studied

Site PreservationSoft Tissue HealingAnterior Dental Aesthetic Area

Investigational drug(s) / intervention(s)

site preservation surgery with open healingsite preservation surgery with close sutures

site preservation surgery with open healing: Tooth extraction in the aesthetic area of the anterior teeth without the expansion and flap were reduced in the operative area. Site preservation surgery was perfomed using Bio-oss (0.5g, Small granule) and Yinlife PCL membrane (25\*25mm size) , with opened wound.

site preservation surgery with close sutures: Tooth extraction in the aesthetic area of the anterior teeth with the expansion and flap were reduced in the operative area. Site preservation surgery was performed using Bio-oss (0.5g, Small granule) and bio-gide (25\*25mm size) . The gums were closely drawn and sutured.

Study summary

In this study, an open healing oral restoration membrane was used for site preservation in the esthetic area after tooth extraction to maintain the space for tooth extraction and bone formation. Clinical observation and cone-beam computed tomography (CBCT) were used to comprehensively evaluate the effect of this operation on promoting the growth of soft and hard tissues, and to provide a new treatment method for site preservation in the esthetic area of clinical anterior teeth.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria: * 1: Age ≥18 years old 2: The affected teeth did not have the conditions for immediate implant placement: thin gingival biotype, labial bone plate thickness \<1 mm, the labial bone plate was missing, the distance between the labial bone plate crest and the cemento-enamel junction\>3 mm 3: No systemic diseases and good oral hygiene 4: Be willing to receive treatment and regular follow-up and review, and signed the informed consent Exclusion Criteria: * 1: Uncontrolled systemic diseases, such as heart, liver and kidney diseases, systemic infections, diabetes, etc 2: Women who are pregnant or lactating 3: Taking bisphosphonates, glucocorticoids and other drugs that affect bone metabolism for a long time or within 5 years 4: Patients receiving oral and maxillofacial radiotherapy in the past five years 5: Patients suffering uncontrolled periodontal disease

Primary outcome measure(s)

  • soft tissue healing efficiency — Immediately after surgery, 7 days, 14 days and 1 month after surgery
    After calibrating the magnification ratio of the tooth extraction wound photos, the reduction ratio of the tooth extraction wound area at 7 days, 14 days, 1 month, and 3 months after surgery was calculated based on the immediate postoperative tooth extraction wound photos to evaluate the soft tissue healing efficiency.

Trial sites (1)

FacilityCityRegionStatus
Stomatology Hospital, Zhejiang University School of Medicine Hangzhou Zhejiang

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07334067 on ClinicalTrials.gov ↗ ← All trials in China