The aim of this observational study is to investigate the potential effects of metformin on postoperative nausea and vomiting (PONV) in patients undergoing surgery under general anesthesia. The primary research question is:
Does preoperative metformin exposure influence the incidence or severity of PONV in patients undergoing general anesthesia? Patients who are already prescribed metformin as part of their routine medical management will be compared with those not taking metformin. Data on PONV occurrence, severity, and recovery outcomes will be collected through structured postoperative surveys administered after surgery.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion criteria
1. Voluntarily sign the informed consent form;
2. Age ≥ 18 years;
3. Patients who require surgical treatment under endotracheal intubation with general anesthesia as determined by the treating physician.
Exclusion criteria
1. Emergency surgery;
2. Currently taking medications with established antiemetic effects (e.g., corticosteroids, antipsychotics) due to underlying medical conditions;
3. Cognitive impairment or psychiatric disorders that preclude cooperation with questionnaire assessments;
4. Anticipated inability to extubate the tracheal tube postoperatively, which would interfere with outcome assessment;
5. Presence of nausea and/or vomiting prior to surgery.
Primary outcome measure(s)
The incidence of PONV during 0-120 postoperative hours — During 0-120 hour after surgery PONV is defined as the occurrence of any of the following symptoms: nausea, retching, or vomiting
Trial sites (1)
Facility
City
Region
Status
The Sixth Affiliated Hospital, Sun Yat-sen University
Guangzhou
Guangdong
Recruiting
More Sixth Affiliated Hospital, Sun Yat-sen University trials in China
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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