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Clinical Trials in China / NCT07244575
Recruiting Observational

Association Between Preoperative Metformin Exposure and Postoperative Nausea and Vomiting in Patients Undergoing General Anesthesia

NCT07244575 · tracked via the Priya Life Science China tracker
Sponsor
Sixth Affiliated Hospital, Sun Yat-sen University
Phase
Observational
Started
2025-12-01
Last updated
2026-02-09

Condition(s) studied

Postoperative Nausea and Vomiting

Study summary

The aim of this observational study is to investigate the potential effects of metformin on postoperative nausea and vomiting (PONV) in patients undergoing surgery under general anesthesia. The primary research question is:

Does preoperative metformin exposure influence the incidence or severity of PONV in patients undergoing general anesthesia? Patients who are already prescribed metformin as part of their routine medical management will be compared with those not taking metformin. Data on PONV occurrence, severity, and recovery outcomes will be collected through structured postoperative surveys administered after surgery.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion criteria 1. Voluntarily sign the informed consent form; 2. Age ≥ 18 years; 3. Patients who require surgical treatment under endotracheal intubation with general anesthesia as determined by the treating physician. Exclusion criteria 1. Emergency surgery; 2. Currently taking medications with established antiemetic effects (e.g., corticosteroids, antipsychotics) due to underlying medical conditions; 3. Cognitive impairment or psychiatric disorders that preclude cooperation with questionnaire assessments; 4. Anticipated inability to extubate the tracheal tube postoperatively, which would interfere with outcome assessment; 5. Presence of nausea and/or vomiting prior to surgery.

Primary outcome measure(s)

  • The incidence of PONV during 0-120 postoperative hours — During 0-120 hour after surgery
    PONV is defined as the occurrence of any of the following symptoms: nausea, retching, or vomiting

Trial sites (1)

FacilityCityRegionStatus
The Sixth Affiliated Hospital, Sun Yat-sen University Guangzhou Guangdong Recruiting

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Other trials for the same condition

A Randomized Controlled Trial Comparing the Effects of Different Anesthetic Sedatives on PONV in Laparoscopic Cholecystectomy Active, not recruiting
Effects of taVNS Combined With Dexmedetomidine on POVN Recruiting
Dexamethasone Palmitate for PONV After Open Surgery Recruiting
Dexamethasone Palmitate for PONV After Craniotomy Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07244575 on ClinicalTrials.gov ↗ ← All trials in China