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Recruiting Phase 1/2

A Study of SHR-7367 With Anti-tumor Agents in Patients With Solid Tumors

NCT07229586 · tracked via the Priya Life Science China tracker
Phase
Phase 1/2
Started
2025-12-02
Last updated
2025-12-19

Condition(s) studied

Solid Tumor

Investigational drug(s) / intervention(s)

SHR-7367 InjectionSHR-1316 Injection →Paclitaxel for Injection →Gemcitabine Hydrochloride for Injection →

SHR-7367 Injection: SHR-7367 injection.

SHR-1316 Injection: SHR-1316 injection.

Paclitaxel for Injection: Paclitaxel for injection (Albumin Bound).

Gemcitabine Hydrochloride for Injection: Gemcitabine Hydrochloride for injection.

Study summary

This study aims to evaluate the safety and preliminary efficacy of SHR-7367 in combination with antineoplastic agents in subjects with advanced solid tumors, and to determine the maximum tolerated dose (MTD) and the recommended Phase II dose (RP2D).

Eligibility

Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria: 1. Be able and willing to provide a written informed consent. 2. Age 18-75 years old (inclusive) at the time of signing the informed consent form. 3. ECOG performance status 0-1. 4. Life expectancy is not less than 12 weeks. 5. At least one measurable lesion per RECIST v1.1. 6. Adequate organ and marrow function as defined by the protocol. Exclusion Criteria: 1. Presence of uncontrollable psychiatric illness and other conditions such as known alcoholism, drug or substance abuse, criminal detention, etc., that affect the completion of the study procedures. 2. Known hypersensitivity to any component of SHR-7367; History of severe allergic reactions to other monoclonal antibodies/fusion protein drugs; Known history of severe hypersensitivity to antineoplastic agents in combination. 3. Subjects who are participating in other clinical studies or whose first dose is less than 4 weeks from the end of the previous clinical study (last dose). 4. Surgery or chemotherapy within 4 weeks of the first dose of study treatment. 5. Active HBV/HCV/HIV infection. 6. Untreated and/or uncontrolled brain metastases. 7. Any other condition that, in the judgment of the investigator, may increase the risk of participating in the study, interfere with the results of the study, or be unsuitable for participation in this study.

Primary outcome measure(s)

  • Stage 1 (IB Period): Dose-limiting toxicity (DLT). — Up to 28 days.
  • Stage 1 (IB Period): Adverse events (AEs). — About 1 year.
  • Stage 1 (IB Period): Serious adverse events (SAEs). — About 1 year.
  • Phase II: Investigator-assessed objective response rate (ORR). — Assessed every 6 weeks, about 1 year.

Trial sites (1)

FacilityCityRegionStatus
Tianjin Medical University Cancer Institute and Hospital Tianjin Tianjin Municipality Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07229586 on ClinicalTrials.gov ↗ ← All trials in China