Clinical Trials in China / NCT07185646
Active, not recruiting
Observational
Mechanistic Study of SPARC-Mediated Regulation of Neutrophil Extracellular Trap Formation in the Brain Metastatic Microenvironment of Breast Cancer
NCT07185646 · tracked via the Priya Life Science China tracker
Condition(s) studied
Neuro-OncologyMRI ImagingTumor Immune Microenvironment
Study summary
The objective of this observational study is to investigate the characteristics of the tumor microenvironment in patients with brain tumors using multi-modal magnetic resonance imaging (MRI). The primary research question it aims to address is:
• Can multi-modal MRI effectively characterize features of the immune microenvironment in brain tumor patients?
Participants:
Eligible participants who have been diagnosed with a brain tumor will undergo multi-modal MRI scans for detailed assessment of tumor microenvironment features.
Eligibility
Inclusion Criteria:
1. conventional MRI revealed intracranial space-occupying lesions and suspected high-grade gliomas, brain metastases and meningiomas；
2. It is planned to perform a brain tumor resection surgery in this institution.
Exclusion Criteria:
1. other CNS diseases in addition to brain tumors;
2. pathologically confirmed brain tumors not belonging to any of the three selected types;
3. contraindications to the use of gadolinium contrast, including hypersensitivity to contrast agents, renal dysfunction, pregnancy or lactation;
4. contraindications to MRI;
5. poor image quality unsuitable for subsequent analyses;
6. age younger than 18 years.
Primary outcome measure(s)
- Postoperative Progression-Free Survival — 6months，12months，24months
Postoperative Progression-Free Survival is defined as the time interval from the date of surgical intervention until the first occurrence of either documented disease progression or death from any cause
Trial sites (1)
| Facility | City | Region | Status |
|---|---|---|---|
| the Second Xiangya Hospital of Central South University | Changsha | Hunan |
More Second Xiangya Hospital of Central South University trials in China
Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07185646 on ClinicalTrials.gov ↗ ← All trials in China