Effects Of Berberine Plus Inulin On Diabetes Care in Patients With LADA

Inclusion Criteria: 1. Diabetes diagnosed according to the report of WHO in 1999； 2. Meet the Chinese Diabetes Society diagnostic criteria (2012) for LADA: (1)glutamic acid decarboxylase antibody (GADA) positive; (2) age at diagnosis ≧ 18 years old; (3) independent on insulin for more than 6 months after diagnosis; 3. Aged between 18 and 70 years old; 4. 7.0%≤HbA1c ≤10.0%; 5. BMI ≥ 18.5 kg/m2, and no more than 37.5 kg/m2; 6. Written informed consent from the patient or family representative. Exclusion Criteria: 1. Severe liver dysfunction (ALT and AST greater than 3 times the upper limit of detection); 2. eGFR \< 50ml/(min • 1.73 m2); 3. Evidence of acute or chronic infection affecting glycemic control within 4 weeks prior to the first visit; 4. History of any malignancy; 5. Pregnancy, breastfeeding, or planned pregnancy during the study period; 6. Secondary diabetes; 7. Presence of acute complications (ketoacidosis, lactic acidosis or hyperosmolar coma); 8. Severe organic heart disease, including but not limited to congenital heart disease, rheumatic heart disease, hypertrophic or dilated cardiomyopathy, etc., New York Heart Association (NYHA) heart function classification ≥Grade III; 9. Chronic use of systemic glucocorticoids or other immunosuppressive agents for over 3 months，or use of antibiotic medications or other interventions that could affect the gastrointestinal tract for 2 months before the screening and during the whole study period. 10. History of hemolytic anemia or glucose-6-phosphate dehydrogenase deficiency. 11. Allergic to berberine or any components in the combinations.