Construction and Application of Precise Diagnosis and Treatment System for Thyroid-associated Ophthalmopathy

Condition(s) studied

Investigational drug(s) / intervention(s)

Imaging and ocular examinations: 2D and 3D Facial photography, blinking videos, orbital CT and MRI images, fundus images and images of nine gaze positions are taken. Clinical information is recorded. Quality of life is assessed. Ocular examinations, such as visual acuity, levator function, exophthalmos measurement, strabismus test, visual field examination, axial length measurement, OCT, OCTA are made.

Study summary

This study aims to develop the deep learning-based system that integrates multimodal information to automatically diagnose, stage, and grade thyroid-associated ophthalmopathy (TAO), assist in treatment decision-making, and predict patient prognosis, thereby providing novel tools to support clinical management.

Eligibility

Primary outcome measure(s)

• eye morphological parameters — through study completion, average of 5 years
  Margin reflex distances(mm)
• Blinking feature of patients with thyroid-associated ophthalmopathy — through study completion, average of 5 years
  Blinking frequency
• Ocular movement measurement — through study completion, average of 5 years
  Ocular movement ability in nine gaze positions
• Automatic orbital structures segmentation and measurement using deep learning methods — through study completion, average of 5 years
  Automatic segmentation and measurement of orbital structures,such as eyeball, extraocular muscle, orbital fat, bony orbital region, optic nerves, etc
• Automatic diagnosis, grading, staging and prediction of patients with thyroid-associated ophthalmopathy — through study completion, average of 5 years
  Patients with thyroid-associated ophthalmopathy(TAO) are classified as TAO or non-TAO. Grading is classified as mild, moderate, severe and sight-threatening. Staging is classified as active and stable.
• three-dimensional eye parameters — through study completion, average of 5 years
  eyelid volume

Trial sites (1)

More Second Affiliated Hospital, Zhejiang University, School of Medicine trials in China

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