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Clinical Trials in China / NCT06984510
Recruiting Observational

Accelerated Biological Aging is Associated With Increased Risk of T2DM in the MASLD Population

NCT06984510 · tracked via the Priya Life Science China tracker
Sponsor
Ningbo No. 1 Hospital
Phase
Observational
Started
2025-04-01
Last updated
2025-06-04

Condition(s) studied

Type 2 Diabetes Mellitus (T2DM)Metabolic Dysfunction-Associated Steatotic Liver DiseaseBiological Age

Investigational drug(s) / intervention(s)

Observational

Observational: Observational

Study summary

The association between biological aging and type 2 diabetes mellitus (T2DM) incidence in individuals with and without metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear.We assessed biological age by calculating phenotypic age (PhenoAge), Klemera-Doubal method (KDMAge), and homeostatic dysregulation (HDAge). To examine the association of biological ageing with the risk of T2DM, cox regression models were conducted. Furthermore, we applied survival analysis, restricted cubic spline models and population attributable fraction (PAF) to further evaluate the association between biological ageing and T2DM incidence.

Eligibility

Sex
ALL
Min age
20 Years
Max age
90 Years
Healthy volunteers
No
Inclusion Criteria: 1. Abdominal ultrasound data available in annual health check-up records 2. At least one of the following five metabolic indicators recorded annually: (1) Body mass index (BMI) or waist circumference (2) Blood pressure (3) Serum triglycerides (4) High-density lipoprotein cholesterol (HDL-C) (5) Fasting plasma glucose or glycated hemoglobin (HbA1c) Exclusion Criteria: 1. Age \<20 or \>90 years 2. Other causes of hepatic steatosis (e.g., alcoholic liver disease or hepatitis B infection) 3. Type 2 diabetes mellitus at baseline 4. Missing baseline data for any of the following variables: systolic blood pressure, albumin, alkaline phosphatase, blood urea nitrogen, creatinine, glycated hemoglobin (HbA1c), total cholesterol, lymphocyte percentage, white blood cell count, mean corpuscular volume, uric acid, fasting plasma glucose, and red cell distribution width (RDW)

Primary outcome measure(s)

  • Incidence of onset T2DM — through study completion, an average of 3 year

Trial sites (1)

FacilityCityRegionStatus
the First Affiliated Hospital of Ningbo University Ningbo, Zhejiang, China, 315000 Ningbo Zhejiang Recruiting

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An Observational Study on the Safety and Efficacy of Henagliflozin in Chinese Patients With Type 2 Diabetes Recruiting
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Liver Fat as a Dietary Target of the Chinese Medical Nutrition Therapy (CMNT) Diet for Treating Type 2 Diabetes With Nonalcoholic Fatty Liver Disease (Version 3.0) Recruiting
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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06984510 on ClinicalTrials.gov ↗ ← All trials in China